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ANO5

GENERAL INFORMATION

Gene name

 ANO5

Gene description

 Anoctamin 5

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (parathyroid gland)
GTEx:Tissue enhanced (skeletal muscle)
FANTOM5:Tissue enhanced (heart muscle, skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression, mainly in CNS, heart and skeletal muscle.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA058857
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (parathyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skeletal muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (heart muscle, skeletal muscle)

GENE INFORMATION

Gene name

 ANO5 (HGNC Symbol)

Synonyms

 GDD1, LGMD2L, TMEM16E

Description

 Anoctamin 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the anoctamin family of transmembrane proteins. The encoded protein is likely a calcium activated chloride channel. Mutations in this gene have been associated with gnathodiaphyseal dysplasia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]

Chromosome

 11

Cytoband

 p14.3

Chromosome location (bp)

 22193176 - 22283357

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171714 (version 83.38)

Entrez gene

 203859

UniProt

 Q75V66 (UniProt - Evidence at protein level)

neXtProt

 NX_Q75V66

Antibodypedia

 ANO5 antibodies

PROTEIN BROWSER
ANO5-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ANO5-001
ENSP00000315371
ENST00000324559
Q75V66 [Direct mapping]
Anoctamin-5
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Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
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GO:0005229 [intracellular calcium activated chloride channel activity]
GO:0005622 [intracellular]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0006821 [chloride transport]
GO:0016021 [integral component of membrane]
GO:0031982 [vesicle]
GO:0034220 [ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:1902476 [chloride transmembrane transport]
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 913 aa
107.2 kDa 		No 9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.