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EXOSC10

GENERAL INFORMATION

Gene name

 EXOSC10

Gene description

 Exosome component 10

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nucleolar expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA028470 , HPA028484 , CAB037141
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and thyroid cancer (favourable).
Liver cancer p<0.001
Thyroid cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Skin cancer

STAINING SUMMARY
HPA028470
HPA028484
CAB037141

GENE INFORMATION

Gene name

 EXOSC10 (HGNC Symbol)

Synonyms

 p2, p3, p4, PM-Scl, PM/Scl-100, PMSCL2, RRP6, Rrp6p

Description

 Exosome component 10 (HGNC Symbol)

Entrez gene summary

Chromosome

 1

Cytoband

 p36.22

Chromosome location (bp)

 11066618 - 11099881

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171824 (version 83.38)

Entrez gene

 5394

UniProt

 Q01780 (UniProt - Evidence at protein level)

neXtProt

 NX_Q01780

Antibodypedia

 EXOSC10 antibodies

PROTEIN BROWSER
EXOSC10-001
EXOSC10-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EXOSC10-001
ENSP00000366135
ENST00000376936
Q01780 [Direct mapping]
Exosome component 10
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0000176 [nuclear exosome (RNase complex)]
GO:0000178 [exosome (RNase complex)]
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000460 [maturation of 5.8S rRNA]
GO:0000956 [nuclear-transcribed mRNA catabolic process]
GO:0003676 [nucleic acid binding]
GO:0003824 [catalytic activity]
GO:0004532 [exoribonuclease activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006396 [RNA processing]
GO:0008408 [3'-5' exonuclease activity]
GO:0009048 [dosage compensation by inactivation of X chromosome]
GO:0016020 [membrane]
GO:0035327 [transcriptionally active chromatin]
GO:0044237 [cellular metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0071028 [nuclear mRNA surveillance]
GO:0071034 [CUT catabolic process]
GO:0071035 [nuclear polyadenylation-dependent rRNA catabolic process]
GO:0071044 [histone mRNA catabolic process]
GO:0071048 [nuclear retention of unspliced pre-mRNA at the site of transcription]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
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 885 aa
100.8 kDa 		No 0
EXOSC10-002
ENSP00000307307
ENST00000304457
Q01780 [Direct mapping]
Exosome component 10
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000176 [nuclear exosome (RNase complex)]
GO:0000178 [exosome (RNase complex)]
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000460 [maturation of 5.8S rRNA]
GO:0000956 [nuclear-transcribed mRNA catabolic process]
GO:0003676 [nucleic acid binding]
GO:0003824 [catalytic activity]
GO:0004532 [exoribonuclease activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006396 [RNA processing]
GO:0008408 [3'-5' exonuclease activity]
GO:0016020 [membrane]
GO:0035327 [transcriptionally active chromatin]
GO:0044237 [cellular metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0071028 [nuclear mRNA surveillance]
GO:0071034 [CUT catabolic process]
GO:0071035 [nuclear polyadenylation-dependent rRNA catabolic process]
GO:0071044 [histone mRNA catabolic process]
GO:0071048 [nuclear retention of unspliced pre-mRNA at the site of transcription]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
Show all
 860 aa
98.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.