Cell atlas - RRM2 - The Human Protein Atlas

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RRM2

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	RRM2
Gene description	Ribonucleotide reductase M2
Protein class	Enzymes FDA approved drug targets Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (supported)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by custom assay

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA056994
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA056994	A-431	Cytosol	Intensity
	HPA056994	U-2 OS	Cytosol	Intensity	Intensity
	HPA056994	U-251 MG	Cytosol	Intensity

CUSTOM DATA


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Thumbnail	Antibody	Cell line	Assay	Description
	HPA056994	U-2 OS	Image	Staining of U-2 OS FUCCI cells, to characterize the cell cycle dependency of the protein expression pattern. The FUCCI cells, Fluorescence Ubiquitination Cell Cycle Indicator, are cells tagged with different fluorescent proteins fused to two different cell cycle regulators Cdt1 (expressed in G1 phase) and Geminin (expressed in S and G2 phases) that allows cell cycle monitoring. When both proteins are present, the overlay of the images appear in yellow marking the G1/S transition. RRM2 is mostly expressed during S and/or G2, and during Mitosis.

CELL CYCLE
Summary	Expression has cell cycle dependency according to custom assay
Intensity variation	Cytosol

GENE INFORMATION
Gene name	RRM2
Synonyms
Description	Ribonucleotide reductase M2 (HGNC Symbol)
Entrez gene summary	This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009]
Chromosome	2
Cytoband	p25.1
Chromosome location (bp)	10122328 - 10131419
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171848 (version 83.38)
Entrez gene	6241
UniProt	P31350 (UniProt - Evidence at protein level)
neXtProt	NX_P31350
Antibodypedia	RRM2 antibodies

PROTEIN BROWSER

RRM2-001	RRM2-010	RRM2-013	RRM2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RRM2-001 ENSP00000353770 ENST00000360566	P31350 [Direct mapping] Ribonucleoside-diphosphate reductase subunit M2 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0004748 [ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005971 [ribonucleoside-diphosphate reductase complex] GO:0006260 [DNA replication] GO:0009186 [deoxyribonucleoside diphosphate metabolic process] GO:0009262 [deoxyribonucleotide metabolic process] GO:0009263 [deoxyribonucleotide biosynthetic process] GO:0015949 [nucleobase-containing small molecule interconversion] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0051259 [protein oligomerization] GO:0051290 [protein heterotetramerization] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	449 aa 51.1 kDa	No	1
RRM2-010 ENSP00000419177 ENST00000474701	C9JXC1 [Direct mapping] Ribonucleoside-diphosphate reductase subunit M2 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0009186 [deoxyribonucleoside diphosphate metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	289 aa 33.8 kDa	No	0
RRM2-013 ENSP00000302955 ENST00000304567	P31350 [Direct mapping] Ribonucleoside-diphosphate reductase subunit M2 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0004748 [ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005971 [ribonucleoside-diphosphate reductase complex] GO:0006260 [DNA replication] GO:0009186 [deoxyribonucleoside diphosphate metabolic process] GO:0009263 [deoxyribonucleotide biosynthetic process] GO:0015949 [nucleobase-containing small molecule interconversion] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	389 aa 44.9 kDa	No	1
RRM2-201 ENSP00000484183 ENST00000615152	P31350 [Direct mapping] Ribonucleoside-diphosphate reductase subunit M2 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0004748 [ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005971 [ribonucleoside-diphosphate reductase complex] GO:0006260 [DNA replication] GO:0009186 [deoxyribonucleoside diphosphate metabolic process] GO:0009263 [deoxyribonucleotide biosynthetic process] GO:0015949 [nucleobase-containing small molecule interconversion] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	449 aa 51.1 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.