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RRM2

GENERAL INFORMATION

Gene name

 RRM2

Gene description

 Ribonucleotide reductase M2

Protein class

 Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Tissue enhanced (esophagus)
FANTOM5:Tissue enhanced (appendix, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Membranous and cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA056994
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Rectum

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix, tonsil)

GENE INFORMATION

Gene name

 RRM2

Synonyms

Description

 Ribonucleotide reductase M2 (HGNC Symbol)

Entrez gene summary

 This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009]

Chromosome

 2

Cytoband

 p25.1

Chromosome location (bp)

 10122328 - 10131419

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171848 (version 83.38)

Entrez gene

 6241

UniProt

 P31350 (UniProt - Evidence at protein level)

neXtProt

 NX_P31350

Antibodypedia

 RRM2 antibodies

PROTEIN BROWSER
RRM2-001
RRM2-010
RRM2-013
RRM2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RRM2-001
ENSP00000353770
ENST00000360566
P31350 [Direct mapping]
Ribonucleoside-diphosphate reductase subunit M2
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004748 [ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005971 [ribonucleoside-diphosphate reductase complex]
GO:0006260 [DNA replication]
GO:0009186 [deoxyribonucleoside diphosphate metabolic process]
GO:0009262 [deoxyribonucleotide metabolic process]
GO:0009263 [deoxyribonucleotide biosynthetic process]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0051259 [protein oligomerization]
GO:0051290 [protein heterotetramerization]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
Show all
 449 aa
51.1 kDa 		No 1
RRM2-010
ENSP00000419177
ENST00000474701
C9JXC1 [Direct mapping]
Ribonucleoside-diphosphate reductase subunit M2
Show all
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0009186 [deoxyribonucleoside diphosphate metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 289 aa
33.8 kDa 		No 0
RRM2-013
ENSP00000302955
ENST00000304567
P31350 [Direct mapping]
Ribonucleoside-diphosphate reductase subunit M2
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004748 [ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005971 [ribonucleoside-diphosphate reductase complex]
GO:0006260 [DNA replication]
GO:0009186 [deoxyribonucleoside diphosphate metabolic process]
GO:0009263 [deoxyribonucleotide biosynthetic process]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
Show all
 389 aa
44.9 kDa 		No 1
RRM2-201
ENSP00000484183
ENST00000615152
P31350 [Direct mapping]
Ribonucleoside-diphosphate reductase subunit M2
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004748 [ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005971 [ribonucleoside-diphosphate reductase complex]
GO:0006260 [DNA replication]
GO:0009186 [deoxyribonucleoside diphosphate metabolic process]
GO:0009263 [deoxyribonucleotide biosynthetic process]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
Show all
 449 aa
51.1 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.