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This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
P60484 [Direct mapping] Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN F6KD01 [Target identity:100%; Query identity:100%] Phosphatase and tensin-like protein; Phosphatase and tensin-like protein isoform A
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Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000287 [magnesium ion binding] GO:0001525 [angiogenesis] GO:0001933 [negative regulation of protein phosphorylation] GO:0002902 [regulation of B cell apoptotic process] GO:0004438 [phosphatidylinositol-3-phosphatase activity] GO:0004721 [phosphoprotein phosphatase activity] GO:0004722 [protein serine/threonine phosphatase activity] GO:0004725 [protein tyrosine phosphatase activity] GO:0005161 [platelet-derived growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006470 [protein dephosphorylation] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0006915 [apoptotic process] GO:0007092 [activation of APC-Cdc20 complex activity] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007270 [neuron-neuron synaptic transmission] GO:0007416 [synapse assembly] GO:0007417 [central nervous system development] GO:0007507 [heart development] GO:0007568 [aging] GO:0007584 [response to nutrient] GO:0007611 [learning or memory] GO:0007613 [memory] GO:0007626 [locomotory behavior] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0008283 [cell proliferation] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0008289 [lipid binding] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009749 [response to glucose] GO:0009898 [cytoplasmic side of plasma membrane] GO:0010033 [response to organic substance] GO:0010035 [response to inorganic substance] GO:0010043 [response to zinc ion] GO:0010467 [gene expression] GO:0010975 [regulation of neuron projection development] GO:0010997 [anaphase-promoting complex binding] GO:0014067 [negative regulation of phosphatidylinositol 3-kinase signaling] GO:0014070 [response to organic cyclic compound] GO:0016311 [dephosphorylation] GO:0016314 [phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity] GO:0016324 [apical plasma membrane] GO:0016477 [cell migration] GO:0016605 [PML body] GO:0016791 [phosphatase activity] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0021542 [dentate gyrus development] GO:0021955 [central nervous system neuron axonogenesis] GO:0030165 [PDZ domain binding] GO:0030336 [negative regulation of cell migration] GO:0030534 [adult behavior] GO:0031175 [neuron projection development] GO:0031642 [negative regulation of myelination] GO:0031647 [regulation of protein stability] GO:0031658 [negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle] GO:0032228 [regulation of synaptic transmission, GABAergic] GO:0032286 [central nervous system myelin maintenance] GO:0032355 [response to estradiol] GO:0032535 [regulation of cellular component size] GO:0033032 [regulation of myeloid cell apoptotic process] GO:0033198 [response to ATP] GO:0033555 [multicellular organismal response to stress] GO:0035176 [social behavior] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0035749 [myelin sheath adaxonal region] GO:0036294 [cellular response to decreased oxygen levels] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042493 [response to drug] GO:0042711 [maternal behavior] GO:0042802 [identical protein binding] GO:0042995 [cell projection] GO:0043005 [neuron projection] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043197 [dendritic spine] GO:0043220 [Schmidt-Lanterman incisure] GO:0043491 [protein kinase B signaling] GO:0043542 [endothelial cell migration] GO:0043647 [inositol phosphate metabolic process] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0045211 [postsynaptic membrane] GO:0045471 [response to ethanol] GO:0045475 [locomotor rhythm] GO:0045792 [negative regulation of cell size] GO:0046621 [negative regulation of organ growth] GO:0046685 [response to arsenic-containing substance] GO:0046855 [inositol phosphate dephosphorylation] GO:0046856 [phosphatidylinositol dephosphorylation] GO:0048008 [platelet-derived growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048679 [regulation of axon regeneration] GO:0048738 [cardiac muscle tissue development] GO:0048853 [forebrain morphogenesis] GO:0048854 [brain morphogenesis] GO:0050680 [negative regulation of epithelial cell proliferation] GO:0050765 [negative regulation of phagocytosis] GO:0050771 [negative regulation of axonogenesis] GO:0050821 [protein stabilization] GO:0050852 [T cell receptor signaling pathway] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051717 [inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity] GO:0051726 [regulation of cell cycle] GO:0051800 [phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity] GO:0051895 [negative regulation of focal adhesion assembly] GO:0051898 [negative regulation of protein kinase B signaling] GO:0060024 [rhythmic synaptic transmission] GO:0060070 [canonical Wnt signaling pathway] GO:0060074 [synapse maturation] GO:0060134 [prepulse inhibition] GO:0060179 [male mating behavior] GO:0060291 [long-term synaptic potentiation] GO:0060292 [long term synaptic depression] GO:0060341 [regulation of cellular localization] GO:0060736 [prostate gland growth] GO:0060997 [dendritic spine morphogenesis] GO:0061002 [negative regulation of dendritic spine morphogenesis] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0071456 [cellular response to hypoxia] GO:0090071 [negative regulation of ribosome biogenesis] GO:0090344 [negative regulation of cell aging] GO:0090394 [negative regulation of excitatory postsynaptic potential] GO:0097105 [presynaptic membrane assembly] GO:0097107 [postsynaptic density assembly] GO:2000060 [positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle] GO:2000463 [positive regulation of excitatory postsynaptic potential] GO:2000808 [negative regulation of synaptic vesicle clustering] GO:2001235 [positive regulation of apoptotic signaling pathway]