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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

PTEN

Gene description

Phosphatase and tensin homolog

Protein class

Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Uncertain based on 2 antibodies.
HPA031335 , CAB004076
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Melanoma

STAINING SUMMARY

HPA031335
CAB004076

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Rare case of lung, pancreatic and liver cancers displayed strong cytoplasmic staining with additional membranous positivity in few tissues. Several cases of prostate cancers along with few cases of melanomas, breast, ovarian and renal cancers were moderately positive. Remaining cancer tissues were weakly stained or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Melanomas, ovarian and breast cancers showed moderate cytoplasmic positivity. Remaining cancer tissues were weakly stained or negative.

GENE INFORMATION

Gene name

PTEN (HGNC Symbol)

Synonyms

BZS, MHAM, MMAC1, PTEN1, TEP1

Description

Phosphatase and tensin homolog (HGNC Symbol)

Entrez gene summary

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]

Chromosome

10

Cytoband

q23.31

Chromosome location (bp)

87863113 - 87971930

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000171862 (version 83.38)

Entrez gene

5728

UniProt

P60484 (UniProt - Evidence at protein level)

neXtProt

NX_P60484

Antibodypedia

PTEN antibodies

PROTEIN BROWSER

PTEN-001
PTEN-005
PTEN-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTEN-001
ENSP00000361021
ENST00000371953
P60484 [Direct mapping]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
F6KD01 [Target identity:100%; Query identity:100%]
Phosphatase and tensin-like protein; Phosphatase and tensin-like protein isoform A
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000287 [magnesium ion binding]
GO:0001525 [angiogenesis]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0002902 [regulation of B cell apoptotic process]
GO:0004438 [phosphatidylinositol-3-phosphatase activity]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005161 [platelet-derived growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006470 [protein dephosphorylation]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0006915 [apoptotic process]
GO:0007092 [activation of APC-Cdc20 complex activity]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007270 [neuron-neuron synaptic transmission]
GO:0007416 [synapse assembly]
GO:0007417 [central nervous system development]
GO:0007507 [heart development]
GO:0007568 [aging]
GO:0007584 [response to nutrient]
GO:0007611 [learning or memory]
GO:0007613 [memory]
GO:0007626 [locomotory behavior]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008289 [lipid binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009749 [response to glucose]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0010033 [response to organic substance]
GO:0010035 [response to inorganic substance]
GO:0010043 [response to zinc ion]
GO:0010467 [gene expression]
GO:0010975 [regulation of neuron projection development]
GO:0010997 [anaphase-promoting complex binding]
GO:0014067 [negative regulation of phosphatidylinositol 3-kinase signaling]
GO:0014070 [response to organic cyclic compound]
GO:0016311 [dephosphorylation]
GO:0016314 [phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity]
GO:0016324 [apical plasma membrane]
GO:0016477 [cell migration]
GO:0016605 [PML body]
GO:0016791 [phosphatase activity]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0021542 [dentate gyrus development]
GO:0021955 [central nervous system neuron axonogenesis]
GO:0030165 [PDZ domain binding]
GO:0030336 [negative regulation of cell migration]
GO:0030534 [adult behavior]
GO:0031175 [neuron projection development]
GO:0031642 [negative regulation of myelination]
GO:0031647 [regulation of protein stability]
GO:0031658 [negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle]
GO:0032228 [regulation of synaptic transmission, GABAergic]
GO:0032286 [central nervous system myelin maintenance]
GO:0032355 [response to estradiol]
GO:0032535 [regulation of cellular component size]
GO:0033032 [regulation of myeloid cell apoptotic process]
GO:0033198 [response to ATP]
GO:0033555 [multicellular organismal response to stress]
GO:0035176 [social behavior]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0035749 [myelin sheath adaxonal region]
GO:0036294 [cellular response to decreased oxygen levels]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042493 [response to drug]
GO:0042711 [maternal behavior]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043005 [neuron projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043197 [dendritic spine]
GO:0043220 [Schmidt-Lanterman incisure]
GO:0043491 [protein kinase B signaling]
GO:0043542 [endothelial cell migration]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0045211 [postsynaptic membrane]
GO:0045471 [response to ethanol]
GO:0045475 [locomotor rhythm]
GO:0045792 [negative regulation of cell size]
GO:0046621 [negative regulation of organ growth]
GO:0046685 [response to arsenic-containing substance]
GO:0046855 [inositol phosphate dephosphorylation]
GO:0046856 [phosphatidylinositol dephosphorylation]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048679 [regulation of axon regeneration]
GO:0048738 [cardiac muscle tissue development]
GO:0048853 [forebrain morphogenesis]
GO:0048854 [brain morphogenesis]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0050765 [negative regulation of phagocytosis]
GO:0050771 [negative regulation of axonogenesis]
GO:0050821 [protein stabilization]
GO:0050852 [T cell receptor signaling pathway]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051717 [inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity]
GO:0051726 [regulation of cell cycle]
GO:0051800 [phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0060024 [rhythmic synaptic transmission]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060074 [synapse maturation]
GO:0060134 [prepulse inhibition]
GO:0060179 [male mating behavior]
GO:0060291 [long-term synaptic potentiation]
GO:0060292 [long term synaptic depression]
GO:0060341 [regulation of cellular localization]
GO:0060736 [prostate gland growth]
GO:0060997 [dendritic spine morphogenesis]
GO:0061002 [negative regulation of dendritic spine morphogenesis]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071456 [cellular response to hypoxia]
GO:0090071 [negative regulation of ribosome biogenesis]
GO:0090344 [negative regulation of cell aging]
GO:0090394 [negative regulation of excitatory postsynaptic potential]
GO:0097105 [presynaptic membrane assembly]
GO:0097107 [postsynaptic density assembly]
GO:2000060 [positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
GO:2000808 [negative regulation of synaptic vesicle clustering]
GO:2001235 [positive regulation of apoptotic signaling pathway]
Show all
403 aa
47.2 kDa
No 0
PTEN-005
ENSP00000483066
ENST00000472832
A0A087X033 [Direct mapping]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
153 aa
17.8 kDa
No 0
PTEN-201
ENSP00000477517
ENST00000610634
A0A087WT17 [Direct mapping]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0006470 [protein dephosphorylation]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
Show all
156 aa
17.7 kDa
No 0

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The Human Protein Atlas project is funded
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