Several cases of hepatocellular carcinomas along with a few cases of renal and prostate cancers displayed moderate cytoplasmic staining and in a few cases nuclear positivity. Other cancers were weakly stained or negative.
ADRA1D (HGNC Symbol)
ADRA1, ADRA1A, ADRA1R
Adrenoceptor alpha 1D (HGNC Symbol)
Entrez gene summary
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. [provided by RefSeq, Jul 2008]