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ADRA1D

GENERAL INFORMATION

Gene name

 ADRA1D

Gene description

 Adrenoceptor alpha 1D

Protein class

 FDA approved drug targets
G-protein coupled receptors
Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cervix, uterine, prostate)
GTEx:Mixed
FANTOM5:Tissue enhanced (cervix, uterine, hippocampus)

Protein evidence

 Evidence at transcript level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA038789
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cervix, uterine, prostate)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cervix, uterine, hippocampus)

GENE INFORMATION

Gene name

 ADRA1D (HGNC Symbol)

Synonyms

 ADRA1, ADRA1A, ADRA1R

Description

 Adrenoceptor alpha 1D (HGNC Symbol)

Entrez gene summary

 Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 p13

Chromosome location (bp)

 4220631 - 4249074

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000171873 (version 83.38)

Entrez gene

 146

UniProt

 P25100 (UniProt - Evidence at transcript level)

neXtProt

 NX_P25100

Antibodypedia

 ADRA1D antibodies

PROTEIN BROWSER
ADRA1D-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADRA1D-001
ENSP00000368766
ENST00000379453
P25100 [Direct mapping]
Alpha-1D adrenergic receptor
B0ZBE0 [Target identity:100%; Query identity:100%]
Adrenergic, alpha-1D-, receptor
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G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001986 [negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure]
GO:0001994 [norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure]
GO:0004930 [G-protein coupled receptor activity]
GO:0004937 [alpha1-adrenergic receptor activity]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006259 [DNA metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007267 [cell-cell signaling]
GO:0007275 [multicellular organismal development]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0016021 [integral component of membrane]
GO:0045907 [positive regulation of vasoconstriction]
GO:0045987 [positive regulation of smooth muscle contraction]
GO:0071880 [adenylate cyclase-activating adrenergic receptor signaling pathway]
Show all
 572 aa
60.5 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.