Cell atlas - AQP4 - The Human Protein Atlas

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AQP4

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cell Junctions
	Plasma membrane

Human cell
	Plasma Membrane

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GENERAL INFORMATION
Gene name	AQP4
Gene description	Aquaporin 4
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane & cell junctions.
RNA cell category	Cell line enhanced (AF22, RPTEC TERT1)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (supported), Cell Junctions (supported)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. CAB005079 , HPA014784
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AF22, RPTEC TERT1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane & cell junctions.

Main location

Plasma membrane (supported), Cell Junctions (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA014784	A-431	Plasma membrane
	HPA014784	A-431	Cell Junctions
	HPA014784	U-2 OS	No staining
	HPA014784	U-251 MG	Plasma membrane
	CAB005079	A-431	Cell Junctions
	CAB005079	U-2 OS	No staining
	CAB005079	U-251 MG	No staining

GENE INFORMATION
Gene name	AQP4 (HGNC Symbol)
Synonyms	MIWC
Description	Aquaporin 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2015]
Chromosome	18
Cytoband	q11.2
Chromosome location (bp)	26852038 - 26865818
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171885 (version 83.38)
Entrez gene	361
UniProt	P55087 (UniProt - Evidence at protein level)
neXtProt	NX_P55087
Antibodypedia	AQP4 antibodies

PROTEIN BROWSER

AQP4-001	AQP4-002	AQP4-003	AQP4-005	AQP4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AQP4-001 ENSP00000372654 ENST00000383168	P55087 [Direct mapping] Aquaporin-4 F1DSG4 [Target identity:100%; Query identity:100%] Aquaporin 4 transcript variant a; Aquaporin 4, isoform CRA_a Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003091 [renal water homeostasis] GO:0005215 [transporter activity] GO:0005372 [water transmembrane transporter activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006833 [water transport] GO:0009897 [external side of plasma membrane] GO:0009992 [cellular water homeostasis] GO:0015250 [water channel activity] GO:0015254 [glycerol channel activity] GO:0015793 [glycerol transport] GO:0016020 [membrane] GO:0016323 [basolateral plasma membrane] GO:0034220 [ion transmembrane transport] GO:0050891 [multicellular organismal water homeostasis] GO:0055085 [transmembrane transport] GO:0071346 [cellular response to interferon-gamma] Show all	323 aa 34.8 kDa	No	6
AQP4-002 ENSP00000462075 ENST00000578776	J3KRM4 [Direct mapping] Aquaporin-4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006833 [water transport] GO:0009992 [cellular water homeostasis] GO:0015250 [water channel activity] GO:0015254 [glycerol channel activity] GO:0015793 [glycerol transport] GO:0016020 [membrane] GO:0016323 [basolateral plasma membrane] GO:0034220 [ion transmembrane transport] Show all	185 aa 19.2 kDa	No	4
AQP4-003 ENSP00000462597 ENST00000581374	P55087 [Direct mapping] Aquaporin-4 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003091 [renal water homeostasis] GO:0005215 [transporter activity] GO:0005372 [water transmembrane transporter activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006833 [water transport] GO:0009897 [external side of plasma membrane] GO:0009992 [cellular water homeostasis] GO:0015250 [water channel activity] GO:0015254 [glycerol channel activity] GO:0015793 [glycerol transport] GO:0016020 [membrane] GO:0016323 [basolateral plasma membrane] GO:0034220 [ion transmembrane transport] GO:0050891 [multicellular organismal water homeostasis] GO:0055085 [transmembrane transport] GO:0071346 [cellular response to interferon-gamma] Show all	301 aa 32.3 kDa	No	6
AQP4-005 ENSP00000393121 ENST00000440832	P55087 [Direct mapping] Aquaporin-4 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003091 [renal water homeostasis] GO:0005215 [transporter activity] GO:0005372 [water transmembrane transporter activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006833 [water transport] GO:0009897 [external side of plasma membrane] GO:0009992 [cellular water homeostasis] GO:0015250 [water channel activity] GO:0015254 [glycerol channel activity] GO:0015793 [glycerol transport] GO:0016020 [membrane] GO:0016323 [basolateral plasma membrane] GO:0034220 [ion transmembrane transport] GO:0050891 [multicellular organismal water homeostasis] GO:0055085 [transmembrane transport] GO:0071346 [cellular response to interferon-gamma] Show all	301 aa 32.3 kDa	No	6
AQP4-201 ENSP00000484446 ENST00000622234	V9PBN7 [Direct mapping] Aquaporin 4 isoform delta4; Aquaporin-4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006833 [water transport] GO:0009992 [cellular water homeostasis] GO:0015250 [water channel activity] GO:0015254 [glycerol channel activity] GO:0015793 [glycerol transport] GO:0016020 [membrane] GO:0016323 [basolateral plasma membrane] GO:0034220 [ion transmembrane transport] Show all	296 aa 31.8 kDa	No	5

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.