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AQP4
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    TISSUE

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    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA
MOUSE BRAIN

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

AQP4

Gene description

Aquaporin 4

Protein class

Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Group enriched (cerebral cortex, lung)
GTEx:Tissue enhanced (caudate, cerebral cortex, hippocampus, hypothalamus)
FANTOM5:Group enriched (brain, caudate, cerebellum, hippocampus)

Protein evidence

Evidence at protein level

Protein expression

Selective expression in CNS, lung, thyroid gland and stomach.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA014784 , CAB005079 , CAB058689
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Lung

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebral cortex, lung)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate, cerebral cortex, hippocampus, hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (brain, caudate, cerebellum, hippocampus)

GENE INFORMATION

Gene name

AQP4 (HGNC Symbol)

Synonyms

MIWC

Description

Aquaporin 4 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2015]

Chromosome

18

Cytoband

q11.2

Chromosome location (bp)

26852038 - 26865818

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000171885 (version 83.38)

Entrez gene

361

UniProt

P55087 (UniProt - Evidence at protein level)

neXtProt

NX_P55087

Antibodypedia

AQP4 antibodies

PROTEIN BROWSER

AQP4-001
AQP4-002
AQP4-003
AQP4-005
AQP4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AQP4-001
ENSP00000372654
ENST00000383168
P55087 [Direct mapping]
Aquaporin-4
F1DSG4 [Target identity:100%; Query identity:100%]
Aquaporin 4 transcript variant a; Aquaporin 4, isoform CRA_a
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003091 [renal water homeostasis]
GO:0005215 [transporter activity]
GO:0005372 [water transmembrane transporter activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006833 [water transport]
GO:0009897 [external side of plasma membrane]
GO:0009992 [cellular water homeostasis]
GO:0015250 [water channel activity]
GO:0015254 [glycerol channel activity]
GO:0015793 [glycerol transport]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0034220 [ion transmembrane transport]
GO:0050891 [multicellular organismal water homeostasis]
GO:0055085 [transmembrane transport]
GO:0071346 [cellular response to interferon-gamma]
Show all
323 aa
34.8 kDa
No 6
AQP4-002
ENSP00000462075
ENST00000578776
J3KRM4 [Direct mapping]
Aquaporin-4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006833 [water transport]
GO:0009992 [cellular water homeostasis]
GO:0015250 [water channel activity]
GO:0015254 [glycerol channel activity]
GO:0015793 [glycerol transport]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0034220 [ion transmembrane transport]
Show all
185 aa
19.2 kDa
No 4
AQP4-003
ENSP00000462597
ENST00000581374
P55087 [Direct mapping]
Aquaporin-4
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003091 [renal water homeostasis]
GO:0005215 [transporter activity]
GO:0005372 [water transmembrane transporter activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006833 [water transport]
GO:0009897 [external side of plasma membrane]
GO:0009992 [cellular water homeostasis]
GO:0015250 [water channel activity]
GO:0015254 [glycerol channel activity]
GO:0015793 [glycerol transport]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0034220 [ion transmembrane transport]
GO:0050891 [multicellular organismal water homeostasis]
GO:0055085 [transmembrane transport]
GO:0071346 [cellular response to interferon-gamma]
Show all
301 aa
32.3 kDa
No 6
AQP4-005
ENSP00000393121
ENST00000440832
P55087 [Direct mapping]
Aquaporin-4
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003091 [renal water homeostasis]
GO:0005215 [transporter activity]
GO:0005372 [water transmembrane transporter activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006833 [water transport]
GO:0009897 [external side of plasma membrane]
GO:0009992 [cellular water homeostasis]
GO:0015250 [water channel activity]
GO:0015254 [glycerol channel activity]
GO:0015793 [glycerol transport]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0034220 [ion transmembrane transport]
GO:0050891 [multicellular organismal water homeostasis]
GO:0055085 [transmembrane transport]
GO:0071346 [cellular response to interferon-gamma]
Show all
301 aa
32.3 kDa
No 6
AQP4-201
ENSP00000484446
ENST00000622234
V9PBN7 [Direct mapping]
Aquaporin 4 isoform delta4; Aquaporin-4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006833 [water transport]
GO:0009992 [cellular water homeostasis]
GO:0015250 [water channel activity]
GO:0015254 [glycerol channel activity]
GO:0015793 [glycerol transport]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0034220 [ion transmembrane transport]
Show all
296 aa
31.8 kDa
No 5

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