Expression of SCG2 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SCG2
Gene description	Secretogranin II
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (glioma, pancreatic cancer)
HPA (cell line):	Cell line enhanced (ASC TERT1, SCLC-21H, SH-SY5Y, WM-115)
HPA (normal tissue):	Group enriched (adrenal gland, cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in CNS and gastrointestinal tract as well as in a few remaining tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Approved based on 2 antibodies. HPA011893 , CAB002519
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and pancreatic cancer (favourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (glioma, pancreatic cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA011893	CAB002519

GENE INFORMATION
Gene name	SCG2 (HGNC Symbol)
Synonyms	CHGC, SgII, SN
Description	Secretogranin II (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q36.1
Chromosome location (bp)	223596940 - 223602503
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171951 (version 83.38)
Entrez gene	7857
UniProt	P13521 (UniProt - Evidence at protein level)
neXtProt	NX_P13521
Antibodypedia	SCG2 antibodies

PROTEIN BROWSER

SCG2-001	SCG2-002	SCG2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SCG2-001 ENSP00000304133 ENST00000305409	P13521 [Direct mapping] Secretogranin-2 Secretoneurin Manserin Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0001525 [angiogenesis] GO:0001937 [negative regulation of endothelial cell proliferation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0005125 [cytokine activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0006954 [inflammatory response] GO:0009306 [protein secretion] GO:0030141 [secretory granule] GO:0035556 [intracellular signal transduction] GO:0042056 [chemoattractant activity] GO:0043542 [endothelial cell migration] GO:0048245 [eosinophil chemotaxis] GO:0050918 [positive chemotaxis] GO:0050930 [induction of positive chemotaxis] GO:2000352 [negative regulation of endothelial cell apoptotic process] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] Show all	617 aa 70.9 kDa	Yes	0
SCG2-002 ENSP00000415468 ENST00000433889	C9JDT0 [Direct mapping] Secretogranin-2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0030141 [secretory granule] Show all	125 aa 14.4 kDa	Yes	0
SCG2-003 ENSP00000394702 ENST00000421386	C9JQI2 [Direct mapping] Secretogranin-2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0030141 [secretory granule] Show all	144 aa 16.5 kDa	Yes	0