Tissue expression of SCG2 - Summary - The Human Protein Atlas

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SCG2

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA
MOUSE BRAIN

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SCG2
Gene description	Secretogranin II
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (adrenal gland, cerebral cortex)
GTEx:	Tissue enhanced (hypothalamus, pituitary gland)
FANTOM5:	Group enriched (caudate, pituitary gland)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in CNS and gastrointestinal tract as well as in a few remaining tissues.

DATA RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Approved based on 2 antibodies. HPA011893 , CAB002519
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (adrenal gland, cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (hypothalamus, pituitary gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (caudate, pituitary gland)

GENE INFORMATION
Gene name	SCG2 (HGNC Symbol)
Synonyms	CHGC, SgII, SN
Description	Secretogranin II (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q36.1
Chromosome location (bp)	223596940 - 223602503
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171951 (version 83.38)
Entrez gene	7857
UniProt	P13521 (UniProt - Evidence at protein level)
neXtProt	NX_P13521
Antibodypedia	SCG2 antibodies

PROTEIN BROWSER

SCG2-001	SCG2-002	SCG2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SCG2-001 ENSP00000304133 ENST00000305409	P13521 [Direct mapping] Secretogranin-2 Secretoneurin Manserin Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0001525 [angiogenesis] GO:0001937 [negative regulation of endothelial cell proliferation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0005125 [cytokine activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0006954 [inflammatory response] GO:0009306 [protein secretion] GO:0030141 [secretory granule] GO:0035556 [intracellular signal transduction] GO:0042056 [chemoattractant activity] GO:0043542 [endothelial cell migration] GO:0048245 [eosinophil chemotaxis] GO:0050918 [positive chemotaxis] GO:0050930 [induction of positive chemotaxis] GO:2000352 [negative regulation of endothelial cell apoptotic process] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] Show all	617 aa 70.9 kDa	Yes	0
SCG2-002 ENSP00000415468 ENST00000433889	C9JDT0 [Direct mapping] Secretogranin-2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0030141 [secretory granule] Show all	125 aa 14.4 kDa	Yes	0
SCG2-003 ENSP00000394702 ENST00000421386	C9JQI2 [Direct mapping] Secretogranin-2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0030141 [secretory granule] Show all	144 aa 16.5 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.