Expression of TPSAB1 in cancer - Summary - The Human Protein Atlas

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TPSAB1

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TPSAB1
Gene description	Tryptase alpha/beta 1
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enriched (HMC-1)
HPA (normal tissue):	Tissue enhanced (gallbladder)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in subsets of leukocytes, probably mast cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data. Caution, targets protein from more than one gene. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 4 antibodies. HPA049153 , HPA049554 , CAB016369 , CAB022175
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable).
Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA049153	HPA049554	CAB016369	CAB022175

GENE INFORMATION
Gene name	TPSAB1 (HGNC Symbol)
Synonyms	TPS1, TPS2, TPSB1
Description	Tryptase alpha/beta 1 (HGNC Symbol)
Entrez gene summary	Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	1240696 - 1242554
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172236 (version 83.38)
Entrez gene	7177
UniProt	Q15661 (UniProt - Evidence at protein level)
neXtProt	NX_Q15661
Antibodypedia	TPSAB1 antibodies

PROTEIN BROWSER

TPSAB1-001	TPSAB1-002	TPSAB1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TPSAB1-001 ENSP00000343577 ENST00000338844	Q15661 [Direct mapping] Tryptase alpha/beta-1 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0006952 [defense response] GO:0008236 [serine-type peptidase activity] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0031012 [extracellular matrix] Show all	275 aa 30.5 kDa	Yes	0
TPSAB1-002 ENSP00000418247 ENST00000461509	J3QTS8 [Direct mapping] Tryptase alpha/beta-1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	282 aa 31.3 kDa	Yes	0
TPSAB1-004 ENSP00000456821 ENST00000561736	A0A0C4DGM1 [Direct mapping] Tryptase alpha/beta-1 Show all	SPOCTOPUS predicted membrane proteins SignalP predicted secreted proteins Predicted intracellular proteins Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	213 aa 23.9 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.