Cell atlas - CLEC7A - The Human Protein Atlas

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CLEC7A

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm
	Vesicles

Human cell
	Nucleoplasm
	Vesicles

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GENERAL INFORMATION
Gene name	CLEC7A
Gene description	C-type lectin domain family 7, member A
Protein class	Disease related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to vesicles.
RNA cell category	Group enriched (Karpas-707, U-266/84)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (uncertain)
Additional location	In addition localized to the Vesicles (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA043244 , HPA050229
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (Karpas-707, U-266/84) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to vesicles.

Main location

Nucleoplasm (uncertain)

Additional location

Vesicles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA043244	A-431	Nucleoplasm
	HPA043244	A-431	Vesicles
	HPA043244	RT4	Nucleoplasm
	HPA043244	U-2 OS	Nucleoplasm
	HPA043244	U-2 OS	Vesicles
	HPA050229	RT4	Nucleoplasm
	HPA050229	RT4	Vesicles
	HPA050229	U-2 OS	Nucleoplasm
	HPA050229	U-2 OS	Vesicles	Intensity
	HPA050229	U-251 MG	Nucleoplasm

GENE INFORMATION
Gene name	CLEC7A (HGNC Symbol)
Synonyms	CD369, CLECSF12, dectin-1, hDectin-1
Description	C-type lectin domain family 7, member A (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	p13.2
Chromosome location (bp)	10116777 - 10130258
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172243 (version 83.38)
Entrez gene	64581
UniProt	Q9BXN2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BXN2
Antibodypedia	CLEC7A antibodies

PROTEIN BROWSER

CLEC7A-001	CLEC7A-003	CLEC7A-004	CLEC7A-009	CLEC7A-012	CLEC7A-013	CLEC7A-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLEC7A-001 ENSP00000266456 ENST00000353231	Q9BXN2 [Direct mapping] C-type lectin domain family 7 member A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Show all	GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006910 [phagocytosis, recognition] GO:0006954 [inflammatory response] GO:0008037 [cell recognition] GO:0008329 [signaling pattern recognition receptor activity] GO:0009756 [carbohydrate mediated signaling] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] GO:0042110 [T cell activation] GO:0042287 [MHC protein binding] GO:0042832 [defense response to protozoan] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] Show all	201 aa 22.6 kDa	No	1
CLEC7A-003 ENSP00000312089 ENST00000310002	Q9BXN2 [Direct mapping] C-type lectin domain family 7 member A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Show all	GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006910 [phagocytosis, recognition] GO:0006954 [inflammatory response] GO:0008037 [cell recognition] GO:0008329 [signaling pattern recognition receptor activity] GO:0009756 [carbohydrate mediated signaling] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] GO:0042110 [T cell activation] GO:0042287 [MHC protein binding] GO:0042832 [defense response to protozoan] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] Show all	77 aa 8.4 kDa	No	1
CLEC7A-004 ENSP00000379743 ENST00000396484	Q9BXN2 [Direct mapping] C-type lectin domain family 7 member A Show all	Predicted intracellular proteins Disease related genes Show all	GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006910 [phagocytosis, recognition] GO:0006954 [inflammatory response] GO:0008037 [cell recognition] GO:0008329 [signaling pattern recognition receptor activity] GO:0009756 [carbohydrate mediated signaling] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] GO:0042110 [T cell activation] GO:0042287 [MHC protein binding] GO:0042832 [defense response to protozoan] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] Show all	168 aa 19.2 kDa	No	0
CLEC7A-009 ENSP00000431461 ENST00000533022	Q9BXN2 [Direct mapping] C-type lectin domain family 7 member A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Show all	GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006910 [phagocytosis, recognition] GO:0006954 [inflammatory response] GO:0008037 [cell recognition] GO:0008329 [signaling pattern recognition receptor activity] GO:0009756 [carbohydrate mediated signaling] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] GO:0042110 [T cell activation] GO:0042287 [MHC protein binding] GO:0042832 [defense response to protozoan] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] Show all	189 aa 21.1 kDa	No	1
CLEC7A-012 ENSP00000298523 ENST00000298523	Q9BXN2 [Direct mapping] C-type lectin domain family 7 member A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Show all	GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006910 [phagocytosis, recognition] GO:0006954 [inflammatory response] GO:0008037 [cell recognition] GO:0008329 [signaling pattern recognition receptor activity] GO:0009756 [carbohydrate mediated signaling] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] GO:0042110 [T cell activation] GO:0042287 [MHC protein binding] GO:0042832 [defense response to protozoan] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] Show all	143 aa 16 kDa	No	1
CLEC7A-013 ENSP00000302569 ENST00000304084	Q9BXN2 [Direct mapping] C-type lectin domain family 7 member A A0A024RAN9 [Target identity:100%; Query identity:100%] C-type lectin domain family 7, member A, isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Show all	GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002366 [leukocyte activation involved in immune response] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006910 [phagocytosis, recognition] GO:0006954 [inflammatory response] GO:0008037 [cell recognition] GO:0008329 [signaling pattern recognition receptor activity] GO:0009756 [carbohydrate mediated signaling] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] GO:0042110 [T cell activation] GO:0042287 [MHC protein binding] GO:0042832 [defense response to protozoan] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] GO:0071226 [cellular response to molecule of fungal origin] Show all	247 aa 27.6 kDa	No	1
CLEC7A-014 ENSP00000434954 ENST00000525605	Q68D78 [Direct mapping] C-type lectin domain family 7 member A; Putative uncharacterized protein DKFZp686L24211; cDNA FLJ59887, moderately similar to Homo sapiens C-type lectin domain family 7, member A (CLEC7A), transcript variant 4, mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] Show all	136 aa 15.6 kDa	No	2

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.