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CLEC7A

GENERAL INFORMATION

Gene name

 CLEC7A

Gene description

 C-type lectin domain family 7, member A

Protein class

 Disease related genes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Group enriched (Karpas-707, U-266/84)
HPA (normal tissue):Tissue enhanced (appendix)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membrane expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA043244
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA043244

GENE INFORMATION

Gene name

 CLEC7A (HGNC Symbol)

Synonyms

 CD369, CLECSF12, dectin-1, hDectin-1

Description

 C-type lectin domain family 7, member A (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 p13.2

Chromosome location (bp)

 10116777 - 10130258

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172243 (version 83.38)

Entrez gene

 64581

UniProt

 Q9BXN2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BXN2

Antibodypedia

 CLEC7A antibodies

PROTEIN BROWSER
CLEC7A-001
CLEC7A-003
CLEC7A-004
CLEC7A-009
CLEC7A-012
CLEC7A-013
CLEC7A-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CLEC7A-001
ENSP00000266456
ENST00000353231
Q9BXN2 [Direct mapping]
C-type lectin domain family 7 member A
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006910 [phagocytosis, recognition]
GO:0006954 [inflammatory response]
GO:0008037 [cell recognition]
GO:0008329 [signaling pattern recognition receptor activity]
GO:0009756 [carbohydrate mediated signaling]
GO:0016021 [integral component of membrane]
GO:0030246 [carbohydrate binding]
GO:0042110 [T cell activation]
GO:0042287 [MHC protein binding]
GO:0042832 [defense response to protozoan]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
Show all
 201 aa
22.6 kDa 		No 1
CLEC7A-003
ENSP00000312089
ENST00000310002
Q9BXN2 [Direct mapping]
C-type lectin domain family 7 member A
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006910 [phagocytosis, recognition]
GO:0006954 [inflammatory response]
GO:0008037 [cell recognition]
GO:0008329 [signaling pattern recognition receptor activity]
GO:0009756 [carbohydrate mediated signaling]
GO:0016021 [integral component of membrane]
GO:0030246 [carbohydrate binding]
GO:0042110 [T cell activation]
GO:0042287 [MHC protein binding]
GO:0042832 [defense response to protozoan]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
Show all
 77 aa
8.4 kDa 		No 1
CLEC7A-004
ENSP00000379743
ENST00000396484
Q9BXN2 [Direct mapping]
C-type lectin domain family 7 member A
Show all
Predicted intracellular proteins
Disease related genes
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006910 [phagocytosis, recognition]
GO:0006954 [inflammatory response]
GO:0008037 [cell recognition]
GO:0008329 [signaling pattern recognition receptor activity]
GO:0009756 [carbohydrate mediated signaling]
GO:0016021 [integral component of membrane]
GO:0030246 [carbohydrate binding]
GO:0042110 [T cell activation]
GO:0042287 [MHC protein binding]
GO:0042832 [defense response to protozoan]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
Show all
 168 aa
19.2 kDa 		No 0
CLEC7A-009
ENSP00000431461
ENST00000533022
Q9BXN2 [Direct mapping]
C-type lectin domain family 7 member A
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006910 [phagocytosis, recognition]
GO:0006954 [inflammatory response]
GO:0008037 [cell recognition]
GO:0008329 [signaling pattern recognition receptor activity]
GO:0009756 [carbohydrate mediated signaling]
GO:0016021 [integral component of membrane]
GO:0030246 [carbohydrate binding]
GO:0042110 [T cell activation]
GO:0042287 [MHC protein binding]
GO:0042832 [defense response to protozoan]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
Show all
 189 aa
21.1 kDa 		No 1
CLEC7A-012
ENSP00000298523
ENST00000298523
Q9BXN2 [Direct mapping]
C-type lectin domain family 7 member A
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006910 [phagocytosis, recognition]
GO:0006954 [inflammatory response]
GO:0008037 [cell recognition]
GO:0008329 [signaling pattern recognition receptor activity]
GO:0009756 [carbohydrate mediated signaling]
GO:0016021 [integral component of membrane]
GO:0030246 [carbohydrate binding]
GO:0042110 [T cell activation]
GO:0042287 [MHC protein binding]
GO:0042832 [defense response to protozoan]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
Show all
 143 aa
16 kDa 		No 1
CLEC7A-013
ENSP00000302569
ENST00000304084
Q9BXN2 [Direct mapping]
C-type lectin domain family 7 member A
A0A024RAN9 [Target identity:100%; Query identity:100%]
C-type lectin domain family 7, member A, isoform CRA_b
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002366 [leukocyte activation involved in immune response]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006910 [phagocytosis, recognition]
GO:0006954 [inflammatory response]
GO:0008037 [cell recognition]
GO:0008329 [signaling pattern recognition receptor activity]
GO:0009756 [carbohydrate mediated signaling]
GO:0016021 [integral component of membrane]
GO:0030246 [carbohydrate binding]
GO:0042110 [T cell activation]
GO:0042287 [MHC protein binding]
GO:0042832 [defense response to protozoan]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0071226 [cellular response to molecule of fungal origin]
Show all
 247 aa
27.6 kDa 		No 1
CLEC7A-014
ENSP00000434954
ENST00000525605
Q68D78 [Direct mapping]
C-type lectin domain family 7 member A; Putative uncharacterized protein DKFZp686L24211; cDNA FLJ59887, moderately similar to Homo sapiens C-type lectin domain family 7, member A (CLEC7A), transcript variant 4, mRNA
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0016021 [integral component of membrane]
GO:0030246 [carbohydrate binding]
Show all
 136 aa
15.6 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.