Expression of BSG in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	BSG
Gene description	Basigin (Ok blood group)
Protein class	Blood group antigen proteins CD markers Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins Transporters
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression in most cell types, including glandular cells, cells in seminiferous ducts, renal tubules, cardiac myocytes and vascular endothelium in the brain.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA036048 , CAB002427
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), liver cancer (unfavourable) and endometrial cancer (favourable).
Renal cancer p<0.001 Liver cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA036048	CAB002427

GENE INFORMATION
Gene name	BSG (HGNC Symbol)
Synonyms	CD147, EMMPRIN, OK
Description	Basigin (Ok blood group) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	571277 - 583493
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172270 (version 83.38)
Entrez gene	682
UniProt	P35613 (UniProt - Evidence at protein level)
neXtProt	NX_P35613
Antibodypedia	BSG antibodies

PROTEIN BROWSER

BSG-001	BSG-002	BSG-003	BSG-004	BSG-006	BSG-007	BSG-008	BSG-010	BSG-014	BSG-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BSG-001 ENSP00000333769 ENST00000333511	P35613 [Direct mapping] Basigin Show all	CD markers Blood group antigen proteins Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0002080 [acrosomal membrane] GO:0005515 [protein binding] GO:0005537 [mannose binding] GO:0005739 [mitochondrion] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0006090 [pyruvate metabolic process] GO:0007166 [cell surface receptor signaling pathway] GO:0007566 [embryo implantation] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0042383 [sarcolemma] GO:0042470 [melanosome] GO:0042475 [odontogenesis of dentin-containing tooth] GO:0043434 [response to peptide hormone] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0045121 [membrane raft] GO:0046689 [response to mercury ion] GO:0046697 [decidualization] GO:0050900 [leukocyte migration] GO:0051591 [response to cAMP] GO:0070062 [extracellular exosome] GO:0072661 [protein targeting to plasma membrane] Show all	385 aa 42.2 kDa	Yes	1
BSG-002 ENSP00000344707 ENST00000346916	P35613 [Direct mapping] Basigin Show all	CD markers Blood group antigen proteins Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005537 [mannose binding] GO:0005739 [mitochondrion] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0006090 [pyruvate metabolic process] GO:0007166 [cell surface receptor signaling pathway] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0042470 [melanosome] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0050900 [leukocyte migration] GO:0070062 [extracellular exosome] GO:0072661 [protein targeting to plasma membrane] Show all	205 aa 22.8 kDa	No	1
BSG-003 ENSP00000343809 ENST00000353555	P35613 [Direct mapping] Basigin Q54A51 [Target identity:100%; Query identity:100%] Basigin (Ok blood group), isoform CRA_a; Cervical EMMPRIN; cDNA FLJ36018 fis, clone TESTI2016337, highly similar to BASIGIN Show all	CD markers Blood group antigen proteins Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005537 [mannose binding] GO:0005739 [mitochondrion] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0006090 [pyruvate metabolic process] GO:0007166 [cell surface receptor signaling pathway] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0042470 [melanosome] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0050900 [leukocyte migration] GO:0070062 [extracellular exosome] GO:0072661 [protein targeting to plasma membrane] Show all	269 aa 29.2 kDa	Yes	1
BSG-004 ENSP00000478958 ENST00000618006	A0A087WUV8 [Direct mapping] Basigin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	189 aa 20.5 kDa	Yes	1
BSG-006 ENSP00000473664 ENST00000545507	P35613 [Direct mapping] Basigin Show all	CD markers Blood group antigen proteins Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005537 [mannose binding] GO:0005739 [mitochondrion] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0006090 [pyruvate metabolic process] GO:0007166 [cell surface receptor signaling pathway] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0042470 [melanosome] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0050900 [leukocyte migration] GO:0070062 [extracellular exosome] GO:0072661 [protein targeting to plasma membrane] Show all	176 aa 19.4 kDa	No	1
BSG-007 ENSP00000458665 ENST00000573216	I3L192 [Direct mapping] Basigin Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016020 [membrane] Show all	161 aa 17.4 kDa	Yes	0
BSG-008 ENSP00000473393 ENST00000573784	R4GMX5 [Direct mapping] Basigin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016020 [membrane] Show all	84 aa 9.3 kDa	No	0
BSG-010 ENSP00000473528 ENST00000576984	R4GN83 [Direct mapping] Basigin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016020 [membrane] Show all	52 aa 5.7 kDa	No	0
BSG-014 ENSP00000484849 ENST00000613627	A0A087X2B5 [Direct mapping] Basigin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016020 [membrane] Show all	221 aa 23.9 kDa	Yes	1
BSG-015 ENSP00000484624 ENST00000614867	A0A087X215 [Direct mapping] Basigin Show all	MEMSAT3 predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		55 aa 5.5 kDa	Yes	0