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SUCLG2

GENERAL INFORMATION

Gene name

 SUCLG2

Gene description

 Succinate-CoA ligase, GDP-forming, beta subunit

Protein class

 Citric acid cycle related proteins
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA046705 , HPA051998
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and colorectal cancer (favourable).
Renal cancer p<0.001
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA046705
HPA051998

GENE INFORMATION

Gene name

 SUCLG2

Synonyms

Description

 Succinate-CoA ligase, GDP-forming, beta subunit (HGNC Symbol)

Entrez gene summary

 This gene encodes a GTP-specific beta subunit of succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the reversible reaction involving the formation of succinyl-CoA and succinate. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 5 and 12. [provided by RefSeq, Apr 2010]

Chromosome

 3

Cytoband

 p14.1

Chromosome location (bp)

 67360460 - 67654614

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172340 (version 83.38)

Entrez gene

 8801

UniProt

 Q96I99 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96I99

Antibodypedia

 SUCLG2 antibodies

PROTEIN BROWSER
SUCLG2-001
SUCLG2-002
SUCLG2-003
SUCLG2-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SUCLG2-001
ENSP00000307432
ENST00000307227
Q96I99 [Direct mapping]
Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
A0A024R325 [Target identity:100%; Query identity:100%]
Succinyl-CoA ligase subunit beta
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Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Plasma proteins
Citric acid cycle related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003824 [catalytic activity]
GO:0004776 [succinate-CoA ligase (GDP-forming) activity]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005886 [plasma membrane]
GO:0006099 [tricarboxylic acid cycle]
GO:0006104 [succinyl-CoA metabolic process]
GO:0008152 [metabolic process]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
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 432 aa
46.5 kDa 		No 0
SUCLG2-002
ENSP00000419325
ENST00000493112
Q96I99 [Direct mapping]
Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Plasma proteins
Citric acid cycle related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004776 [succinate-CoA ligase (GDP-forming) activity]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005886 [plasma membrane]
GO:0006099 [tricarboxylic acid cycle]
GO:0006104 [succinyl-CoA metabolic process]
GO:0008152 [metabolic process]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
Show all
 440 aa
47.7 kDa 		No 0
SUCLG2-003
ENSP00000417589
ENST00000492795
E9PDQ8 [Direct mapping]
Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
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Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
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 379 aa
41.4 kDa 		No 0
SUCLG2-004
ENSP00000417260
ENST00000460567
H0Y852 [Direct mapping]
Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
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Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
Show all
 190 aa
20.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.