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Malignant tissues displayed weak to moderate granular cytoplasmic staining. A few cases of breast carcinomas and malignant melanomas were strongly positive. Many cases of malignant lymphomas and gliomas, renal, stomach and pancreatic cancers were negative.
GENE INFORMATION
Gene name
RCAN2 (HGNC Symbol)
Synonyms
DSCR1L1, ZAKI-4
Description
Regulator of calcineurin 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the regulator of calcineurin (RCAN) protein family. These proteins play a role in many physiological processes by binding to the catalytic domain of calcineurin A, inhibiting calcineurin-mediated nuclear translocation of the transcription factor NFATC1. Expression of this gene in skin fibroblasts is upregulated by thyroid hormone, and the encoded protein may also play a role in endothelial cell function and angiogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]