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ABCG4

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GENERAL INFORMATION

Gene name

 ABCG4

Gene description

 ATP-binding cassette, sub-family G (WHITE), member 4

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (AN3-CA, U-2 OS)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AN3-CA, U-2 OS)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 ABCG4 (HGNC Symbol)

Synonyms

 WHITE2

Description

 ATP-binding cassette, sub-family G (WHITE), member 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily and is expressed predominantly in liver tissue. The function has not yet been determined but may involve cholesterol transport. Alternate splice variants have been described but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q23.3

Chromosome location (bp)

 119149012 - 119162653

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172350 (version 83.38)

Entrez gene

 64137

UniProt

 Q9H172 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H172

Antibodypedia

 ABCG4 antibodies

PROTEIN BROWSER
ABCG4-001
ABCG4-002
ABCG4-003
ABCG4-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ABCG4-001
ENSP00000481728
ENST00000619701
Q9H172 [Direct mapping]
ATP-binding cassette sub-family G member 4
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0017127 [cholesterol transporter activity]
GO:0033344 [cholesterol efflux]
GO:0034041 [sterol-transporting ATPase activity]
GO:0042803 [protein homodimerization activity]
GO:0046982 [protein heterodimerization activity]
GO:0055085 [transmembrane transport]
Show all
 646 aa
71.9 kDa 		No 7
ABCG4-002
ENSP00000479253
ENST00000615496
Q9H172 [Direct mapping]
ATP-binding cassette sub-family G member 4
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0017127 [cholesterol transporter activity]
GO:0033344 [cholesterol efflux]
GO:0034041 [sterol-transporting ATPase activity]
GO:0042803 [protein homodimerization activity]
GO:0046982 [protein heterodimerization activity]
GO:0055085 [transmembrane transport]
Show all
 646 aa
71.9 kDa 		No 7
ABCG4-003
ENSP00000484289
ENST00000622721
Q9H172 [Direct mapping]
ATP-binding cassette sub-family G member 4
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0017127 [cholesterol transporter activity]
GO:0033344 [cholesterol efflux]
GO:0034041 [sterol-transporting ATPase activity]
GO:0042803 [protein homodimerization activity]
GO:0046982 [protein heterodimerization activity]
GO:0055085 [transmembrane transport]
Show all
 646 aa
71.9 kDa 		No 7
ABCG4-005
ENSP00000431915
ENST00000524604
E9PJ00 [Direct mapping]
ATP-binding cassette sub-family G member 4
Show all
Predicted intracellular proteins
Show all
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
Show all
 152 aa
16.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.