Tissue expression of ABCG4 - Summary - The Human Protein Atlas

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ABCG4

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ABCG4
Gene description	ATP-binding cassette, sub-family G (WHITE), member 4
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (cerebral cortex, parathyroid gland, testis)
GTEx:	Tissue enhanced (cerebellum)
FANTOM5:	Group enriched (brain, caudate, cerebellum, hippocampus, retina, testis)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA040312
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (cerebral cortex, parathyroid gland, testis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebellum)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (brain, caudate, cerebellum, hippocampus, retina, testis)

GENE INFORMATION
Gene name	ABCG4 (HGNC Symbol)
Synonyms	WHITE2
Description	ATP-binding cassette, sub-family G (WHITE), member 4 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily and is expressed predominantly in liver tissue. The function has not yet been determined but may involve cholesterol transport. Alternate splice variants have been described but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q23.3
Chromosome location (bp)	119149012 - 119162653
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172350 (version 83.38)
Entrez gene	64137
UniProt	Q9H172 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H172
Antibodypedia	ABCG4 antibodies

PROTEIN BROWSER

ABCG4-001	ABCG4-002	ABCG4-003	ABCG4-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABCG4-001 ENSP00000481728 ENST00000619701	Q9H172 [Direct mapping] ATP-binding cassette sub-family G member 4 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0017127 [cholesterol transporter activity] GO:0033344 [cholesterol efflux] GO:0034041 [sterol-transporting ATPase activity] GO:0042803 [protein homodimerization activity] GO:0046982 [protein heterodimerization activity] GO:0055085 [transmembrane transport] Show all	646 aa 71.9 kDa	No	7
ABCG4-002 ENSP00000479253 ENST00000615496	Q9H172 [Direct mapping] ATP-binding cassette sub-family G member 4 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0017127 [cholesterol transporter activity] GO:0033344 [cholesterol efflux] GO:0034041 [sterol-transporting ATPase activity] GO:0042803 [protein homodimerization activity] GO:0046982 [protein heterodimerization activity] GO:0055085 [transmembrane transport] Show all	646 aa 71.9 kDa	No	7
ABCG4-003 ENSP00000484289 ENST00000622721	Q9H172 [Direct mapping] ATP-binding cassette sub-family G member 4 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0017127 [cholesterol transporter activity] GO:0033344 [cholesterol efflux] GO:0034041 [sterol-transporting ATPase activity] GO:0042803 [protein homodimerization activity] GO:0046982 [protein heterodimerization activity] GO:0055085 [transmembrane transport] Show all	646 aa 71.9 kDa	No	7
ABCG4-005 ENSP00000431915 ENST00000524604	E9PJ00 [Direct mapping] ATP-binding cassette sub-family G member 4 Show all	Predicted intracellular proteins Show all	GO:0005524 [ATP binding] GO:0008152 [metabolic process] GO:0016887 [ATPase activity] Show all	152 aa 16.8 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.