Cell atlas - GNB2 - The Human Protein Atlas

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GNB2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Plasma membrane

Human cell
	Plasma Membrane

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GENERAL INFORMATION
Gene name	GNB2
Gene description	Guanine nucleotide binding protein (G protein), beta polypeptide 2
Protein class	Predicted intracellular proteins RAS pathway related proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. CAB010032 , HPA040736
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane.

Main location

Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB010032	A-431	Plasma membrane
	CAB010032	U-2 OS	Plasma membrane
	CAB010032	U-251 MG	Plasma membrane
	HPA040736	A-431	Golgi apparatus
	HPA040736	A-431	Plasma membrane
	HPA040736	U-2 OS	Plasma membrane
	HPA040736	U-251 MG	Plasma membrane

GENE INFORMATION
Gene name	GNB2
Synonyms
Description	Guanine nucleotide binding protein (G protein), beta polypeptide 2 (HGNC Symbol)
Entrez gene summary	Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat length polymorphism in its 5' UTR. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q22.1
Chromosome location (bp)	100673531 - 100679174
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172354 (version 83.38)
Entrez gene	2783
UniProt	P62879 (UniProt - Evidence at protein level)
neXtProt	NX_P62879
Antibodypedia	GNB2 antibodies

PROTEIN BROWSER

GNB2-001	GNB2-002	GNB2-003	GNB2-004	GNB2-005	GNB2-006	GNB2-007	GNB2-009	GNB2-010	GNB2-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GNB2-001 ENSP00000305260 ENST00000303210	P62879 [Direct mapping] Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 Q6FHM2 [Target identity:100%; Query identity:100%] GNB2 protein; Guanine nucleotide binding protein (G protein), beta polypeptide 2, isoform CRA_a; cDNA FLJ77321, highly similar to Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2 (GNB2), mRNA Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0005246 [calcium channel regulator activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006112 [energy reserve metabolic process] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0016020 [membrane] GO:0031982 [vesicle] GO:0032403 [protein complex binding] GO:0043209 [myelin sheath] GO:0043234 [protein complex] GO:0044281 [small molecule metabolic process] GO:0044297 [cell body] GO:0048471 [perinuclear region of cytoplasm] GO:0051020 [GTPase binding] GO:0070062 [extracellular exosome] GO:0071377 [cellular response to glucagon stimulus] Show all	340 aa 37.3 kDa	No	0
GNB2-002 ENSP00000401873 ENST00000436220	E7EP32 [Direct mapping] Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007165 [signal transduction] Show all	296 aa 32.4 kDa	No	0
GNB2-003 ENSP00000389391 ENST00000424361	E7EP32 [Direct mapping] Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007165 [signal transduction] Show all	296 aa 32.4 kDa	No	0
GNB2-004 ENSP00000390543 ENST00000419828	P62879 [Direct mapping] Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006112 [energy reserve metabolic process] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0016020 [membrane] GO:0031982 [vesicle] GO:0032403 [protein complex binding] GO:0044281 [small molecule metabolic process] GO:0048471 [perinuclear region of cytoplasm] GO:0051020 [GTPase binding] GO:0070062 [extracellular exosome] GO:0071377 [cellular response to glucagon stimulus] Show all	240 aa 25.9 kDa	No	0
GNB2-005 ENSP00000400286 ENST00000427895	P62879 [Direct mapping] Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006112 [energy reserve metabolic process] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0016020 [membrane] GO:0031982 [vesicle] GO:0032403 [protein complex binding] GO:0044281 [small molecule metabolic process] GO:0048471 [perinuclear region of cytoplasm] GO:0051020 [GTPase binding] GO:0070062 [extracellular exosome] GO:0071377 [cellular response to glucagon stimulus] Show all	240 aa 25.9 kDa	No	0
GNB2-006 ENSP00000377503 ENST00000393926	P62879 [Direct mapping] Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 Q6FHM2 [Target identity:100%; Query identity:100%] GNB2 protein; Guanine nucleotide binding protein (G protein), beta polypeptide 2, isoform CRA_a; cDNA FLJ77321, highly similar to Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2 (GNB2), mRNA Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006112 [energy reserve metabolic process] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0016020 [membrane] GO:0031982 [vesicle] GO:0032403 [protein complex binding] GO:0044281 [small molecule metabolic process] GO:0048471 [perinuclear region of cytoplasm] GO:0051020 [GTPase binding] GO:0070062 [extracellular exosome] GO:0071377 [cellular response to glucagon stimulus] Show all	340 aa 37.3 kDa	No	0
GNB2-007 ENSP00000377501 ENST00000393924	P62879 [Direct mapping] Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 Q6FHM2 [Target identity:100%; Query identity:100%] GNB2 protein; Guanine nucleotide binding protein (G protein), beta polypeptide 2, isoform CRA_a; cDNA FLJ77321, highly similar to Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2 (GNB2), mRNA Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006112 [energy reserve metabolic process] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0016020 [membrane] GO:0031982 [vesicle] GO:0032403 [protein complex binding] GO:0044281 [small molecule metabolic process] GO:0048471 [perinuclear region of cytoplasm] GO:0051020 [GTPase binding] GO:0070062 [extracellular exosome] GO:0071377 [cellular response to glucagon stimulus] Show all	340 aa 37.3 kDa	No	0
GNB2-009 ENSP00000399904 ENST00000451587	C9JXA5 [Direct mapping] Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007165 [signal transduction] Show all	251 aa 27.6 kDa	No	0
GNB2-010 ENSP00000390077 ENST00000431068	C9JIS1 [Direct mapping] Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007165 [signal transduction] Show all	232 aa 25.5 kDa	No	0
GNB2-011 ENSP00000413219 ENST00000412215	C9JZN1 [Direct mapping] Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007165 [signal transduction] Show all	152 aa 17 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.