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GNB2

GENERAL INFORMATION

Gene name

 GNB2

Gene description

 Guanine nucleotide binding protein (G protein), beta polypeptide 2

Protein class

 Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Membranous and cytoplasmic expression at variable levels in several different cell types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 2 antibodies.
HPA040736 , CAB010032
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA040736
CAB010032

GENE INFORMATION

Gene name

 GNB2

Synonyms

Description

 Guanine nucleotide binding protein (G protein), beta polypeptide 2 (HGNC Symbol)

Entrez gene summary

 Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat length polymorphism in its 5' UTR. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q22.1

Chromosome location (bp)

 100673531 - 100679174

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172354 (version 83.38)

Entrez gene

 2783

UniProt

 P62879 (UniProt - Evidence at protein level)

neXtProt

 NX_P62879

Antibodypedia

 GNB2 antibodies

PROTEIN BROWSER
GNB2-001
GNB2-002
GNB2-003
GNB2-004
GNB2-005
GNB2-006
GNB2-007
GNB2-009
GNB2-010
GNB2-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GNB2-001
ENSP00000305260
ENST00000303210
P62879 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
Q6FHM2 [Target identity:100%; Query identity:100%]
GNB2 protein; Guanine nucleotide binding protein (G protein), beta polypeptide 2, isoform CRA_a; cDNA FLJ77321, highly similar to Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2 (GNB2), mRNA
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Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005246 [calcium channel regulator activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006112 [energy reserve metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0016020 [membrane]
GO:0031982 [vesicle]
GO:0032403 [protein complex binding]
GO:0043209 [myelin sheath]
GO:0043234 [protein complex]
GO:0044281 [small molecule metabolic process]
GO:0044297 [cell body]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051020 [GTPase binding]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
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 340 aa
37.3 kDa 		No 0
GNB2-002
ENSP00000401873
ENST00000436220
E7EP32 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
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Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
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 296 aa
32.4 kDa 		No 0
GNB2-003
ENSP00000389391
ENST00000424361
E7EP32 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
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Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
Show all
 296 aa
32.4 kDa 		No 0
GNB2-004
ENSP00000390543
ENST00000419828
P62879 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006112 [energy reserve metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0016020 [membrane]
GO:0031982 [vesicle]
GO:0032403 [protein complex binding]
GO:0044281 [small molecule metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051020 [GTPase binding]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
Show all
 240 aa
25.9 kDa 		No 0
GNB2-005
ENSP00000400286
ENST00000427895
P62879 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006112 [energy reserve metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0016020 [membrane]
GO:0031982 [vesicle]
GO:0032403 [protein complex binding]
GO:0044281 [small molecule metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051020 [GTPase binding]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
Show all
 240 aa
25.9 kDa 		No 0
GNB2-006
ENSP00000377503
ENST00000393926
P62879 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
Q6FHM2 [Target identity:100%; Query identity:100%]
GNB2 protein; Guanine nucleotide binding protein (G protein), beta polypeptide 2, isoform CRA_a; cDNA FLJ77321, highly similar to Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2 (GNB2), mRNA
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006112 [energy reserve metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0016020 [membrane]
GO:0031982 [vesicle]
GO:0032403 [protein complex binding]
GO:0044281 [small molecule metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051020 [GTPase binding]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
Show all
 340 aa
37.3 kDa 		No 0
GNB2-007
ENSP00000377501
ENST00000393924
P62879 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
Q6FHM2 [Target identity:100%; Query identity:100%]
GNB2 protein; Guanine nucleotide binding protein (G protein), beta polypeptide 2, isoform CRA_a; cDNA FLJ77321, highly similar to Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2 (GNB2), mRNA
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006112 [energy reserve metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0016020 [membrane]
GO:0031982 [vesicle]
GO:0032403 [protein complex binding]
GO:0044281 [small molecule metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051020 [GTPase binding]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
Show all
 340 aa
37.3 kDa 		No 0
GNB2-009
ENSP00000399904
ENST00000451587
C9JXA5 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
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 251 aa
27.6 kDa 		No 0
GNB2-010
ENSP00000390077
ENST00000431068
C9JIS1 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
Show all
 232 aa
25.5 kDa 		No 0
GNB2-011
ENSP00000413219
ENST00000412215
C9JZN1 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
Show all
 152 aa
17 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.