Expression of INSL5 in cancer - Summary - The Human Protein Atlas

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INSL5

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	INSL5
Gene description	Insulin-like 5
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (colorectal cancer, prostate cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Group enriched (colon, rectum)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in a subset of neuroendocrine cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA030100 , CAB033849
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (colorectal cancer, prostate cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA030100	CAB033849

GENE INFORMATION
Gene name	INSL5
Synonyms
Description	Insulin-like 5 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene contains a classical signature of the insulin superfamily and is highly similar to relaxin 3 (RLN3/INSL7). [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p31.3
Chromosome location (bp)	66797741 - 66801256
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172410 (version 83.38)
Entrez gene	10022
UniProt	Q9Y5Q6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y5Q6
Antibodypedia	INSL5 antibodies

PROTEIN BROWSER

INSL5-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
INSL5-001 ENSP00000302724 ENST00000304526	Q9Y5Q6 [Direct mapping] Insulin-like peptide INSL5 Insulin-like peptide INSL5 B chain Insulin-like peptide INSL5 A chain Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005179 [hormone activity] GO:0005575 [cellular_component] GO:0005576 [extracellular region] GO:0008150 [biological_process] GO:2000253 [positive regulation of feeding behavior] Show all	135 aa 15.3 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.