Expression of GTPBP2 in cancer - Summary - The Human Protein Atlas

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GTPBP2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GTPBP2
Gene description	GTP binding protein 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA031419
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA031419

GENE INFORMATION
Gene name	GTPBP2
Synonyms
Description	GTP binding protein 2 (HGNC Symbol)
Entrez gene summary	GTP-binding proteins, or G proteins, constitute a superfamily capable of binding GTP or GDP. G proteins are activated by binding GTP and are inactivated by hydrolyzing GTP to GDP. This general mechanism enables G proteins to perform a wide range of biologic activities.[supplied by OMIM, Jan 2003]
Chromosome	6
Cytoband	p21.1
Chromosome location (bp)	43605316 - 43629162
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172432 (version 83.38)
Entrez gene	54676
UniProt	Q9BX10 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BX10
Antibodypedia	GTPBP2 antibodies

PROTEIN BROWSER

GTPBP2-004	GTPBP2-005	GTPBP2-006	GTPBP2-009	GTPBP2-011	GTPBP2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GTPBP2-004 ENSP00000392944 ENST00000419497	H0Y4M5 [Direct mapping] GTP-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		153 aa 16.6 kDa	No	0
GTPBP2-005 ENSP00000398905 ENST00000432918	H0Y5J1 [Direct mapping] GTP-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		154 aa 16.7 kDa	No	0
GTPBP2-006 ENSP00000410676 ENST00000452781	X6RJ09 [Direct mapping] GTP-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		227 aa 24.8 kDa	No	0
GTPBP2-009 ENSP00000411358 ENST00000442748	H0Y7A5 [Direct mapping] GTP-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005525 [GTP binding] GO:0008152 [metabolic process] Show all	316 aa 35.2 kDa	No	0
GTPBP2-011 ENSP00000303997 ENST00000307126	Q9BX10 [Direct mapping] GTP-binding protein 2 A0A024RD30 [Target identity:100%; Query identity:100%] GTP binding protein 2, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003743 [translation initiation factor activity] GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0006413 [translational initiation] GO:0008150 [biological_process] GO:0043231 [intracellular membrane-bounded organelle] Show all	602 aa 65.8 kDa	No	0
GTPBP2-201 ENSP00000304893 ENST00000307114	Q9BX10 [Direct mapping] GTP-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003743 [translation initiation factor activity] GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0006413 [translational initiation] GO:0008150 [biological_process] GO:0043231 [intracellular membrane-bounded organelle] Show all	514 aa 56.6 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.