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ACOT12

GENERAL INFORMATION

Gene name

 ACOT12

Gene description

 Acyl-CoA thioesterase 12

Protein class

 Enzymes
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (liver)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA037723 , HPA037724
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA037723
HPA037724

GENE INFORMATION

Gene name

 ACOT12 (HGNC Symbol)

Synonyms

 Cach, STARD15, THEAL

Description

 Acyl-CoA thioesterase 12 (HGNC Symbol)

Entrez gene summary

Chromosome

 5

Cytoband

 q14.1

Chromosome location (bp)

 81330005 - 81394179

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172497 (version 83.38)

Entrez gene

 134526

UniProt

 Q8WYK0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WYK0

Antibodypedia

 ACOT12 antibodies

PROTEIN BROWSER
ACOT12-001
ACOT12-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACOT12-001
ENSP00000303246
ENST00000307624
Q8WYK0 [Direct mapping]
Acyl-coenzyme A thioesterase 12
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Enzymes
   ENZYME proteins
   Hydrolases
Transporters
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0003986 [acetyl-CoA hydrolase activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006084 [acetyl-CoA metabolic process]
GO:0006090 [pyruvate metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006637 [acyl-CoA metabolic process]
GO:0008289 [lipid binding]
GO:0019432 [triglyceride biosynthetic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0052689 [carboxylic ester hydrolase activity]
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 555 aa
62 kDa 		No 0
ACOT12-002
ENSP00000421628
ENST00000513751
Q8WYK0 [Direct mapping]
Acyl-coenzyme A thioesterase 12
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Enzymes
   ENZYME proteins
   Hydrolases
Transporters
Predicted intracellular proteins
Show all
GO:0003986 [acetyl-CoA hydrolase activity]
GO:0005829 [cytosol]
GO:0006090 [pyruvate metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006637 [acyl-CoA metabolic process]
GO:0008289 [lipid binding]
GO:0019432 [triglyceride biosynthetic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0052689 [carboxylic ester hydrolase activity]
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 167 aa
18.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.