Expression of CTSW in cancer - Summary - The Human Protein Atlas

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CTSW

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CTSW
Gene description	Cathepsin W
Protein class	Enzymes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Group enriched (HEL, NB-4)
HPA (normal tissue):	Tissue enhanced (bone marrow, spleen)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

High cytoplasmic expression in immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. CAB016345
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable), renal cancer (unfavourable), breast cancer (favourable) and head and neck cancer (favourable).
Endometrial cancer p<0.001 Renal cancer p<0.001 Breast cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB016345

GENE INFORMATION
Gene name	CTSW
Synonyms
Description	Cathepsin W (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene, a member of the peptidase C1 family, is a cysteine proteinase that may have a specific function in the mechanism or regulation of T-cell cytolytic activity. The encoded protein is found associated with the membrane inside the endoplasmic reticulum of natural killer and cytotoxic T-cells. Expression of this gene is up-regulated by interleukin-2. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q13.1
Chromosome location (bp)	65879809 - 65883741
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172543 (version 83.38)
Entrez gene	1521
UniProt	P56202 (UniProt - Evidence at protein level)
neXtProt	NX_P56202
Antibodypedia	CTSW antibodies

PROTEIN BROWSER

CTSW-001	CTSW-002	CTSW-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CTSW-001 ENSP00000311300 ENST00000307886	P56202 [Direct mapping] Cathepsin W Show all	Enzymes Peptidases Cysteine-type peptidases SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0005615 [extracellular space] GO:0005764 [lysosome] GO:0006508 [proteolysis] GO:0006955 [immune response] GO:0008234 [cysteine-type peptidase activity] GO:0016020 [membrane] GO:0051603 [proteolysis involved in cellular protein catabolic process] Show all	376 aa 42.1 kDa	Yes	0
CTSW-002 ENSP00000436568 ENST00000528419	E9PI30 [Direct mapping] Cathepsin W Show all	SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0005615 [extracellular space] GO:0005764 [lysosome] GO:0006508 [proteolysis] GO:0008234 [cysteine-type peptidase activity] GO:0051603 [proteolysis involved in cellular protein catabolic process] Show all	364 aa 40.8 kDa	Yes	0
CTSW-004 ENSP00000434267 ENST00000526034	H0YDT2 [Direct mapping] Cathepsin W Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0005615 [extracellular space] GO:0005764 [lysosome] GO:0006508 [proteolysis] GO:0008234 [cysteine-type peptidase activity] GO:0051603 [proteolysis involved in cellular protein catabolic process] Show all	211 aa 23.7 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.