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CORO1B

GENERAL INFORMATION

Gene name

 CORO1B

Gene description

 Coronin, actin binding protein, 1B

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic and membranous expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA070456 , CAB017616
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA070456
CAB017616

GENE INFORMATION

Gene name

 CORO1B (HGNC Symbol)

Synonyms

 coronin-2

Description

 Coronin, actin binding protein, 1B (HGNC Symbol)

Entrez gene summary

 Members of the coronin family, such as CORO1B, are WD repeat-containing actin-binding proteins that regulate cell motility (Cai et al., 2005 [PubMed 16027158]).[supplied by OMIM, Mar 2008]

Chromosome

 11

Cytoband

 q13.2

Chromosome location (bp)

 67435510 - 67443821

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172725 (version 83.38)

Entrez gene

 57175

UniProt

 Q9BR76 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BR76

Antibodypedia

 CORO1B antibodies

PROTEIN BROWSER
CORO1B-001
CORO1B-008
CORO1B-201
CORO1B-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CORO1B-001
ENSP00000340211
ENST00000341356
Q9BR76 [Direct mapping]
Coronin-1B
A0A024R5K1 [Target identity:100%; Query identity:100%]
Coronin
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001725 [stress fiber]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0015629 [actin cytoskeleton]
GO:0016477 [cell migration]
GO:0030027 [lamellipodium]
GO:0030036 [actin cytoskeleton organization]
GO:0031252 [cell leading edge]
GO:0031529 [ruffle organization]
GO:0034315 [regulation of Arp2/3 complex-mediated actin nucleation]
GO:0034316 [negative regulation of Arp2/3 complex-mediated actin nucleation]
GO:0035767 [endothelial cell chemotaxis]
GO:0036120 [cellular response to platelet-derived growth factor stimulus]
GO:0042060 [wound healing]
GO:0042802 [identical protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
GO:0070062 [extracellular exosome]
GO:0071672 [negative regulation of smooth muscle cell chemotaxis]
GO:0071933 [Arp2/3 complex binding]
GO:0071944 [cell periphery]
GO:0090135 [actin filament branching]
GO:1902463 [protein localization to cell leading edge]
GO:2000394 [positive regulation of lamellipodium morphogenesis]
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 489 aa
54.2 kDa 		No 0
CORO1B-008
ENSP00000438056
ENST00000545016
F5H0D2 [Direct mapping]
Coronin
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0015629 [actin cytoskeleton]
GO:0030036 [actin cytoskeleton organization]
GO:0051015 [actin filament binding]
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 139 aa
15.3 kDa 		No 0
CORO1B-201
ENSP00000377471
ENST00000393893
Q9BR76 [Direct mapping]
Coronin-1B
A0A024R5K1 [Target identity:100%; Query identity:100%]
Coronin
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0015629 [actin cytoskeleton]
GO:0016477 [cell migration]
GO:0030027 [lamellipodium]
GO:0030036 [actin cytoskeleton organization]
GO:0031252 [cell leading edge]
GO:0031529 [ruffle organization]
GO:0034315 [regulation of Arp2/3 complex-mediated actin nucleation]
GO:0034316 [negative regulation of Arp2/3 complex-mediated actin nucleation]
GO:0035767 [endothelial cell chemotaxis]
GO:0036120 [cellular response to platelet-derived growth factor stimulus]
GO:0042060 [wound healing]
GO:0042802 [identical protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
GO:0070062 [extracellular exosome]
GO:0071672 [negative regulation of smooth muscle cell chemotaxis]
GO:0071933 [Arp2/3 complex binding]
GO:0071944 [cell periphery]
GO:0090135 [actin filament branching]
GO:1902463 [protein localization to cell leading edge]
GO:2000394 [positive regulation of lamellipodium morphogenesis]
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 489 aa
54.2 kDa 		No 0
CORO1B-202
ENSP00000486585
ENST00000627576
F5H390 [Direct mapping]
Coronin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0015629 [actin cytoskeleton]
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 282 aa
31 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.