Expression of RNASEH2C in cancer - Summary - The Human Protein Atlas

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RNASEH2C

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	RNASEH2C
Gene description	Ribonuclease H2, subunit C
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable) and renal cancer (unfavourable).
Pancreatic cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	RNASEH2C (HGNC Symbol)
Synonyms	AGS3, AYP1
Description	Ribonuclease H2, subunit C (HGNC Symbol)
Entrez gene summary	This gene encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes. Mutations in this gene cause Aicardi-Goutieres syndrome-3, a disease that causes severe neurologic dysfunction. A pseudogene for this gene has been identified on chromosome Y, near the sex determining region Y (SRY) gene. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q13.1
Chromosome location (bp)	65714896 - 65720947
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172922 (version 83.38)
Entrez gene	84153
UniProt	Q8TDP1 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TDP1
Antibodypedia	RNASEH2C antibodies

PROTEIN BROWSER

RNASEH2C-001	RNASEH2C-002	RNASEH2C-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RNASEH2C-001 ENSP00000308193 ENST00000308418	Q8TDP1 [Direct mapping] Ribonuclease H2 subunit C A0A024R5B3 [Target identity:100%; Query identity:100%] AYP1 protein, isoform CRA_b Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004523 [RNA-DNA hybrid ribonuclease activity] GO:0005634 [nucleus] GO:0006401 [RNA catabolic process] GO:0032299 [ribonuclease H2 complex] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] Show all	164 aa 17.8 kDa	No	0
RNASEH2C-002 ENSP00000431555 ENST00000528220	E9PKP0 [Direct mapping] Ribonuclease H2 subunit C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		81 aa 9 kDa	No	0
RNASEH2C-005 ENSP00000432897 ENST00000527610	E9PN81 [Direct mapping] Ribonuclease H2 subunit C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		247 aa 26.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.