Tissue expression of RNASEH2C - Summary

GENERAL INFORMATION
Gene name	RNASEH2C
Gene description	Ribonuclease H2, subunit C
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	RNASEH2C (HGNC Symbol)
Synonyms	AGS3, AYP1
Description	Ribonuclease H2, subunit C (HGNC Symbol)
Entrez gene summary	This gene encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes. Mutations in this gene cause Aicardi-Goutieres syndrome-3, a disease that causes severe neurologic dysfunction. A pseudogene for this gene has been identified on chromosome Y, near the sex determining region Y (SRY) gene. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q13.1
Chromosome location (bp)	65714896 - 65720947
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172922 (version 83.38)
Entrez gene	84153
UniProt	Q8TDP1 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TDP1
Antibodypedia	RNASEH2C antibodies

PROTEIN BROWSER

RNASEH2C-001	RNASEH2C-002	RNASEH2C-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RNASEH2C-001 ENSP00000308193 ENST00000308418	Q8TDP1 [Direct mapping] Ribonuclease H2 subunit C A0A024R5B3 [Target identity:100%; Query identity:100%] AYP1 protein, isoform CRA_b Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004523 [RNA-DNA hybrid ribonuclease activity] GO:0005634 [nucleus] GO:0006401 [RNA catabolic process] GO:0032299 [ribonuclease H2 complex] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] Show all	164 aa 17.8 kDa	No	0
RNASEH2C-002 ENSP00000431555 ENST00000528220	E9PKP0 [Direct mapping] Ribonuclease H2 subunit C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		81 aa 9 kDa	No	0
RNASEH2C-005 ENSP00000432897 ENST00000527610	E9PN81 [Direct mapping] Ribonuclease H2 subunit C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		247 aa 26.3 kDa	No	0