Cell atlas - TADA2B - The Human Protein Atlas

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TADA2B

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear speckles

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	TADA2B
Gene description	Transcriptional adaptor 2B
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear speckles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA035770
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear speckles.

Main location

Nuclear speckles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA035770	A-431	Nuclear speckles
	HPA035770	U-2 OS	Nuclear speckles
	HPA035770	U-251 MG	Nuclear speckles

GENE INFORMATION
Gene name	TADA2B (HGNC Symbol)
Synonyms	MGC21874
Description	Transcriptional adaptor 2B (HGNC Symbol)
Entrez gene summary	TADA2B functions as a transcriptional adaptor protein that potentiates transcription through coordination of histone acetyltransferase (HAT) activity and by linking activation factors to basal transcriptional machinery (Barlev et al., 2003 [PubMed 12972612]).[supplied by OMIM, Apr 2010]
Chromosome	4
Cytoband	p16.1
Chromosome location (bp)	7041899 - 7057952
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173011 (version 83.38)
Entrez gene	93624
UniProt	Q86TJ2 (UniProt - Evidence at protein level)
neXtProt	NX_Q86TJ2
Antibodypedia	TADA2B antibodies

PROTEIN BROWSER

TADA2B-001	TADA2B-002	TADA2B-003	TADA2B-004	TADA2B-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TADA2B-001 ENSP00000308022 ENST00000310074	Q86TJ2 [Direct mapping] Transcriptional adapter 2-beta Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003713 [transcription coactivator activity] GO:0004402 [histone acetyltransferase activity] GO:0005515 [protein binding] GO:0006325 [chromatin organization] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0016573 [histone acetylation] GO:0030914 [STAGA complex] GO:0035066 [positive regulation of histone acetylation] GO:0070461 [SAGA-type complex] Show all	420 aa 48.5 kDa	No	0
TADA2B-002 ENSP00000423947 ENST00000512388	Q86TJ2 [Direct mapping] Transcriptional adapter 2-beta Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003713 [transcription coactivator activity] GO:0004402 [histone acetyltransferase activity] GO:0006325 [chromatin organization] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0016573 [histone acetylation] GO:0035066 [positive regulation of histone acetylation] GO:0070461 [SAGA-type complex] Show all	345 aa 39.9 kDa	No	0
TADA2B-003 ENSP00000423181 ENST00000515646	Q86TJ2 [Direct mapping] Transcriptional adapter 2-beta Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003713 [transcription coactivator activity] GO:0004402 [histone acetyltransferase activity] GO:0006325 [chromatin organization] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0016573 [histone acetylation] GO:0035066 [positive regulation of histone acetylation] GO:0070461 [SAGA-type complex] Show all	328 aa 38 kDa	No	0
TADA2B-004 ENSP00000422398 ENST00000506692	D6RC20 [Direct mapping] Transcriptional adapter 2-beta Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		121 aa 13.5 kDa	No	0
TADA2B-005 ENSP00000425731 ENST00000510704	D6RJ05 [Direct mapping] Transcriptional adapter 2-beta Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		129 aa 14.6 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.