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TADA2B

GENERAL INFORMATION

Gene name

 TADA2B

Gene description

 Transcriptional adaptor 2B

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA035770
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and urothelial cancer (favourable).
Renal cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035770

GENE INFORMATION

Gene name

 TADA2B (HGNC Symbol)

Synonyms

 MGC21874

Description

 Transcriptional adaptor 2B (HGNC Symbol)

Entrez gene summary

 TADA2B functions as a transcriptional adaptor protein that potentiates transcription through coordination of histone acetyltransferase (HAT) activity and by linking activation factors to basal transcriptional machinery (Barlev et al., 2003 [PubMed 12972612]).[supplied by OMIM, Apr 2010]

Chromosome

 4

Cytoband

 p16.1

Chromosome location (bp)

 7041899 - 7057952

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000173011 (version 83.38)

Entrez gene

 93624

UniProt

 Q86TJ2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86TJ2

Antibodypedia

 TADA2B antibodies

PROTEIN BROWSER
TADA2B-001
TADA2B-002
TADA2B-003
TADA2B-004
TADA2B-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TADA2B-001
ENSP00000308022
ENST00000310074
Q86TJ2 [Direct mapping]
Transcriptional adapter 2-beta
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0006325 [chromatin organization]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008270 [zinc ion binding]
GO:0016573 [histone acetylation]
GO:0030914 [STAGA complex]
GO:0035066 [positive regulation of histone acetylation]
GO:0070461 [SAGA-type complex]
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 420 aa
48.5 kDa 		No 0
TADA2B-002
ENSP00000423947
ENST00000512388
Q86TJ2 [Direct mapping]
Transcriptional adapter 2-beta
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0006325 [chromatin organization]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008270 [zinc ion binding]
GO:0016573 [histone acetylation]
GO:0035066 [positive regulation of histone acetylation]
GO:0070461 [SAGA-type complex]
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 345 aa
39.9 kDa 		No 0
TADA2B-003
ENSP00000423181
ENST00000515646
Q86TJ2 [Direct mapping]
Transcriptional adapter 2-beta
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0006325 [chromatin organization]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008270 [zinc ion binding]
GO:0016573 [histone acetylation]
GO:0035066 [positive regulation of histone acetylation]
GO:0070461 [SAGA-type complex]
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 328 aa
38 kDa 		No 0
TADA2B-004
ENSP00000422398
ENST00000506692
D6RC20 [Direct mapping]
Transcriptional adapter 2-beta
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 121 aa
13.5 kDa 		No 0
TADA2B-005
ENSP00000425731
ENST00000510704
D6RJ05 [Direct mapping]
Transcriptional adapter 2-beta
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 129 aa
14.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.