Fields »
ABOUT
HELP
BLOG
HSPA6

GENERAL INFORMATION

Gene name

 HSPA6

Gene description

 Heat shock 70kDa protein 6 (HSP70B')

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enriched (Karpas-707)
HPA (normal tissue):Tissue enhanced (placenta)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression of varying intensity in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification.

Reliability score

 Approved based on 3 antibodies.
HPA028549 , HPA052504 , CAB017452
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Cervical cancer

STAINING SUMMARY
HPA028549
HPA052504
CAB017452

GENE INFORMATION

Gene name

 HSPA6

Synonyms

Description

 Heat shock 70kDa protein 6 (HSP70B') (HGNC Symbol)

Entrez gene summary

Chromosome

 1

Cytoband

 q23.3

Chromosome location (bp)

 161524540 - 161526910

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000173110 (version 83.38)

Entrez gene

 3310

UniProt

 P17066 (UniProt - Evidence at protein level)

neXtProt

 NX_P17066

Antibodypedia

 HSPA6 antibodies

PROTEIN BROWSER
HSPA6-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HSPA6-001
ENSP00000310219
ENST00000309758
P17066 [Direct mapping]
Heat shock 70 kDa protein 6
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0006986 [response to unfolded protein]
GO:0008180 [COP9 signalosome]
GO:0019899 [enzyme binding]
GO:0031072 [heat shock protein binding]
GO:0034605 [cellular response to heat]
GO:0042026 [protein refolding]
GO:0042623 [ATPase activity, coupled]
GO:0051082 [unfolded protein binding]
GO:0070062 [extracellular exosome]
GO:0072562 [blood microparticle]
Show all
 643 aa
71 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.