Expression of LRRN3 in cancer - Summary

GENERAL INFORMATION
Gene name	LRRN3
Gene description	Leucine rich repeat neuronal 3
Protein class	Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (glioma, thyroid cancer)
HPA (cell line):	Cell line enhanced (AF22, BJ hTERT+, SH-SY5Y, T-47d)
HPA (normal tissue):	Tissue enhanced (adrenal gland, cerebral cortex, testis, thyroid gland)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Cytoplasmic and membranous expression in several tissues, highly abundant in brain.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Uncertain based on 2 antibodies. HPA043820 , HPA046792
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (glioma, thyroid cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA043820	HPA046792

GENE INFORMATION
Gene name	LRRN3 (HGNC Symbol)
Synonyms	FIGLER5, FLJ11129, NLRR3
Description	Leucine rich repeat neuronal 3 (HGNC Symbol)
Entrez gene summary
Chromosome	7
Cytoband	q31.1
Chromosome location (bp)	111091006 - 111125454
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000173114 (version 83.38)
Entrez gene	54674
UniProt	Q9H3W5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9H3W5
Antibodypedia	LRRN3 antibodies

PROTEIN BROWSER

LRRN3-001	LRRN3-002	LRRN3-003	LRRN3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LRRN3-001 ENSP00000407927 ENST00000421101	E7EW58 [Direct mapping] Leucine-rich repeat neuronal protein 3 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	273 aa 30.9 kDa	Yes	0
LRRN3-002 ENSP00000412417 ENST00000422987	Q9H3W5 [Direct mapping] Leucine-rich repeat neuronal protein 3 A4D0T1 [Target identity:100%; Query identity:100%] Leucine rich repeat neuronal 3; Leucine rich repeat neuronal 3, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	708 aa 79.4 kDa	Yes	1
LRRN3-003 ENSP00000312001 ENST00000308478	Q9H3W5 [Direct mapping] Leucine-rich repeat neuronal protein 3 A4D0T1 [Target identity:100%; Query identity:100%] Leucine rich repeat neuronal 3; Leucine rich repeat neuronal 3, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	708 aa 79.4 kDa	Yes	1
LRRN3-201 ENSP00000397312 ENST00000451085	Q9H3W5 [Direct mapping] Leucine-rich repeat neuronal protein 3 A4D0T1 [Target identity:100%; Query identity:100%] Leucine rich repeat neuronal 3; Leucine rich repeat neuronal 3, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0051965 [positive regulation of synapse assembly] Show all	708 aa 79.4 kDa	Yes	1