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CYSLTR1

GENERAL INFORMATION

Gene name

 CYSLTR1

Gene description

 Cysteinyl leukotriene receptor 1

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (HL-60, NB-4, RPMI-8226, THP-1, U-937)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective cytoplasmic expression including in immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA010546
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA010546

GENE INFORMATION

Gene name

 CYSLTR1 (HGNC Symbol)

Synonyms

 CysLT(1), CysLT1, CYSLT1R

Description

 Cysteinyl leukotriene receptor 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Chromosome

 X

Cytoband

 q21.1

Chromosome location (bp)

 78271464 - 78327691

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000173198 (version 83.38)

Entrez gene

 10800

UniProt

 Q9Y271 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y271

Antibodypedia

 CYSLTR1 antibodies

PROTEIN BROWSER
CYSLTR1-001
CYSLTR1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CYSLTR1-001
ENSP00000362401
ENST00000373304
Q9Y271 [Direct mapping]
Cysteinyl leukotriene receptor 1
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Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001631 [cysteinyl leukotriene receptor activity]
GO:0003013 [circulatory system process]
GO:0004930 [G-protein coupled receptor activity]
GO:0004974 [leukotriene receptor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006952 [defense response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007218 [neuropeptide signaling pathway]
GO:0007585 [respiratory gaseous exchange]
GO:0008528 [G-protein coupled peptide receptor activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0061737 [leukotriene signaling pathway]
Show all
 337 aa
38.5 kDa 		No 7
CYSLTR1-201
ENSP00000478492
ENST00000614798
Q9Y271 [Direct mapping]
Cysteinyl leukotriene receptor 1
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001631 [cysteinyl leukotriene receptor activity]
GO:0003013 [circulatory system process]
GO:0004930 [G-protein coupled receptor activity]
GO:0004974 [leukotriene receptor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006816 [calcium ion transport]
GO:0006935 [chemotaxis]
GO:0006952 [defense response]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007218 [neuropeptide signaling pathway]
GO:0007585 [respiratory gaseous exchange]
GO:0008528 [G-protein coupled peptide receptor activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0061737 [leukotriene signaling pathway]
Show all
 337 aa
38.5 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.