Tissue expression of CYSLTR1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CYSLTR1
Gene description	Cysteinyl leukotriene receptor 1
Protein class	FDA approved drug targets G-protein coupled receptors Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Tissue enhanced (spleen)
FANTOM5:	Mixed

Protein evidence

Evidence at protein level

Protein expression

Selective cytoplasmic expression including in immune cells.

DATA RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA010546
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Mixed

GENE INFORMATION
Gene name	CYSLTR1 (HGNC Symbol)
Synonyms	CysLT(1), CysLT1, CYSLT1R
Description	Cysteinyl leukotriene receptor 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Chromosome	X
Cytoband	q21.1
Chromosome location (bp)	78271464 - 78327691
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173198 (version 83.38)
Entrez gene	10800
UniProt	Q9Y271 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y271
Antibodypedia	CYSLTR1 antibodies

PROTEIN BROWSER

CYSLTR1-001	CYSLTR1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CYSLTR1-001 ENSP00000362401 ENST00000373304	Q9Y271 [Direct mapping] Cysteinyl leukotriene receptor 1 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0001631 [cysteinyl leukotriene receptor activity] GO:0003013 [circulatory system process] GO:0004930 [G-protein coupled receptor activity] GO:0004974 [leukotriene receptor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006952 [defense response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007218 [neuropeptide signaling pathway] GO:0007585 [respiratory gaseous exchange] GO:0008528 [G-protein coupled peptide receptor activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0061737 [leukotriene signaling pathway] Show all	337 aa 38.5 kDa	No	7
CYSLTR1-201 ENSP00000478492 ENST00000614798	Q9Y271 [Direct mapping] Cysteinyl leukotriene receptor 1 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0001631 [cysteinyl leukotriene receptor activity] GO:0003013 [circulatory system process] GO:0004930 [G-protein coupled receptor activity] GO:0004974 [leukotriene receptor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006816 [calcium ion transport] GO:0006935 [chemotaxis] GO:0006952 [defense response] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007218 [neuropeptide signaling pathway] GO:0007585 [respiratory gaseous exchange] GO:0008528 [G-protein coupled peptide receptor activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0061737 [leukotriene signaling pathway] Show all	337 aa 38.5 kDa	No	7