Expression of SNCG in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SNCG
Gene description	Synuclein, gamma (breast cancer-specific protein 1)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (ovarian cancer, urothelial cancer)
HPA (cell line):	Cell line enhanced (CAPAN-2, RT4)
HPA (normal tissue):	Tissue enhanced (adipose tissue, adrenal gland, urinary bladder)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct expression in the CNS, peripheral nerves, urothelial cells, adrenal cortex, myoepithelial cells in breast and basal cell in epididymis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA014404 , CAB001452 , CAB040581
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and stomach cancer (unfavourable).
Renal cancer p<0.001 Stomach cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (ovarian cancer, urothelial cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA014404	CAB001452	CAB040581

GENE INFORMATION
Gene name	SNCG (HGNC Symbol)
Synonyms	BCSG1, persyn, SR
Description	Synuclein, gamma (breast cancer-specific protein 1) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor development. [provided by RefSeq, Jan 2010]
Chromosome	10
Cytoband	q23.2
Chromosome location (bp)	86958618 - 86963260
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173267 (version 83.38)
Entrez gene	6623
UniProt	O76070 (UniProt - Evidence at protein level)
neXtProt	NX_O76070
Antibodypedia	SNCG antibodies

PROTEIN BROWSER

SNCG-001	SNCG-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SNCG-001 ENSP00000344658 ENST00000348795	F8W754 [Direct mapping] Gamma-synuclein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		126 aa 13.1 kDa	No	0
SNCG-002 ENSP00000361087 ENST00000372017	O76070 [Direct mapping] Gamma-synuclein Q6FHG5 [Target identity:100%; Query identity:100%] Gamma-synuclein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005819 [spindle] GO:0007268 [synaptic transmission] GO:0008344 [adult locomotory behavior] GO:0009306 [protein secretion] GO:0014059 [regulation of dopamine secretion] GO:0030424 [axon] GO:0043025 [neuronal cell body] GO:0046928 [regulation of neurotransmitter secretion] GO:0048471 [perinuclear region of cytoplasm] GO:0050808 [synapse organization] GO:0070062 [extracellular exosome] Show all	127 aa 13.3 kDa	No	0