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SNCG

GENERAL INFORMATION

Gene name

 SNCG

Gene description

 Synuclein, gamma (breast cancer-specific protein 1)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (adipose tissue, adrenal gland, urinary bladder)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Distinct expression in the CNS, peripheral nerves, urothelial cells, adrenal cortex, myoepithelial cells in breast and basal cell in epididymis.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA014404 , CAB001452 , CAB040581
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adipose tissue, adrenal gland, urinary bladder)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SNCG (HGNC Symbol)

Synonyms

 BCSG1, persyn, SR

Description

 Synuclein, gamma (breast cancer-specific protein 1) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor development. [provided by RefSeq, Jan 2010]

Chromosome

 10

Cytoband

 q23.2

Chromosome location (bp)

 86958618 - 86963260

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000173267 (version 83.38)

Entrez gene

 6623

UniProt

 O76070 (UniProt - Evidence at protein level)

neXtProt

 NX_O76070

Antibodypedia

 SNCG antibodies

PROTEIN BROWSER
SNCG-001
SNCG-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SNCG-001
ENSP00000344658
ENST00000348795
F8W754 [Direct mapping]
Gamma-synuclein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 126 aa
13.1 kDa 		No 0
SNCG-002
ENSP00000361087
ENST00000372017
O76070 [Direct mapping]
Gamma-synuclein
Q6FHG5 [Target identity:100%; Query identity:100%]
Gamma-synuclein
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0007268 [synaptic transmission]
GO:0008344 [adult locomotory behavior]
GO:0009306 [protein secretion]
GO:0014059 [regulation of dopamine secretion]
GO:0030424 [axon]
GO:0043025 [neuronal cell body]
GO:0046928 [regulation of neurotransmitter secretion]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050808 [synapse organization]
GO:0070062 [extracellular exosome]
Show all
 127 aa
13.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.