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TRIB1

GENERAL INFORMATION

Gene name

 TRIB1

Gene description

 Tribbles pseudokinase 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TRIB1 (HGNC Symbol)

Synonyms

 C8FW, GIG2, TRB1

Description

 Tribbles pseudokinase 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 8

Cytoband

 q24.13

Chromosome location (bp)

 125430321 - 125438405

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000173334 (version 83.38)

Entrez gene

 10221

UniProt

 Q96RU8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96RU8

Antibodypedia

 TRIB1 antibodies

PROTEIN BROWSER
TRIB1-001
TRIB1-002
TRIB1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRIB1-001
ENSP00000312150
ENST00000311922
Q96RU8 [Direct mapping]
Tribbles homolog 1
Show all
Enzymes
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004860 [protein kinase inhibitor activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0006469 [negative regulation of protein kinase activity]
GO:0007254 [JNK cascade]
GO:0008134 [transcription factor binding]
GO:0014912 [negative regulation of smooth muscle cell migration]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031665 [negative regulation of lipopolysaccharide-mediated signaling pathway]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032496 [response to lipopolysaccharide]
GO:0043405 [regulation of MAP kinase activity]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0045645 [positive regulation of eosinophil differentiation]
GO:0045651 [positive regulation of macrophage differentiation]
GO:0045659 [negative regulation of neutrophil differentiation]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0055106 [ubiquitin-protein transferase regulator activity]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 372 aa
41 kDa 		No 0
TRIB1-002
ENSP00000429063
ENST00000520847
Q96RU8 [Direct mapping]
Tribbles homolog 1
Show all
Enzymes
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004860 [protein kinase inhibitor activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0006469 [negative regulation of protein kinase activity]
GO:0007254 [JNK cascade]
GO:0008134 [transcription factor binding]
GO:0014912 [negative regulation of smooth muscle cell migration]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031665 [negative regulation of lipopolysaccharide-mediated signaling pathway]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032496 [response to lipopolysaccharide]
GO:0043405 [regulation of MAP kinase activity]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0055106 [ubiquitin-protein transferase regulator activity]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 206 aa
23.5 kDa 		No 0
TRIB1-003
ENSP00000428879
ENST00000519576
E5RFH4 [Direct mapping]
Tribbles homolog 1
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
Show all
 141 aa
15.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.