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SAA1

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GENERAL INFORMATION

Gene name

 SAA1

Gene description

 Serum amyloid A1

Protein class

 Disease related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (hTCEpi, A-431, HaCaT, EFO-21)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (hTCEpi, A-431, HaCaT, EFO-21)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 SAA1 (HGNC Symbol)

Synonyms

 PIG4, SAA, TP53I4

Description

 Serum amyloid A1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Jun 2012]

Chromosome

 11

Cytoband

 p15.1

Chromosome location (bp)

 18266174 - 18269977

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000173432 (version 83.38)

Entrez gene

 6288

UniProt

 P0DJI8 (UniProt - Evidence at protein level)

neXtProt

 NX_P0DJI8

Antibodypedia

 SAA1 antibodies

PROTEIN BROWSER
SAA1-001
SAA1-002
SAA1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SAA1-001
ENSP00000348918
ENST00000356524
P0DJI8 [Direct mapping]
Serum amyloid A-1 protein Amyloid protein A Serum amyloid protein A(2-104) Serum amyloid protein A(3-104) Serum amyloid protein A(2-103) Serum amyloid protein A(2-102) Serum amyloid protein A(4-101)
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0001664 [G-protein coupled receptor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0005881 [cytoplasmic microtubule]
GO:0006898 [receptor-mediated endocytosis]
GO:0006953 [acute-phase response]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0008201 [heparin binding]
GO:0030168 [platelet activation]
GO:0030593 [neutrophil chemotaxis]
GO:0034364 [high-density lipoprotein particle]
GO:0042056 [chemoattractant activity]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045785 [positive regulation of cell adhesion]
GO:0048246 [macrophage chemotaxis]
GO:0048247 [lymphocyte chemotaxis]
GO:0050708 [regulation of protein secretion]
GO:0050715 [positive regulation of cytokine secretion]
GO:0050716 [positive regulation of interleukin-1 secretion]
GO:0050728 [negative regulation of inflammatory response]
GO:0050918 [positive chemotaxis]
GO:0070062 [extracellular exosome]
GO:0071682 [endocytic vesicle lumen]
Show all
 122 aa
13.5 kDa 		Yes 0
SAA1-002
ENSP00000436866
ENST00000532858
E9PQD6 [Direct mapping]
Serum amyloid A protein
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006953 [acute-phase response]
GO:0034364 [high-density lipoprotein particle]
GO:0042056 [chemoattractant activity]
GO:0050918 [positive chemotaxis]
Show all
 122 aa
13.5 kDa 		Yes 0
SAA1-003
ENSP00000384906
ENST00000405158
P0DJI8 [Direct mapping]
Serum amyloid A-1 protein Amyloid protein A Serum amyloid protein A(2-104) Serum amyloid protein A(3-104) Serum amyloid protein A(2-103) Serum amyloid protein A(2-102) Serum amyloid protein A(4-101)
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0001664 [G-protein coupled receptor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0005881 [cytoplasmic microtubule]
GO:0006898 [receptor-mediated endocytosis]
GO:0006953 [acute-phase response]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0008201 [heparin binding]
GO:0030168 [platelet activation]
GO:0030593 [neutrophil chemotaxis]
GO:0034364 [high-density lipoprotein particle]
GO:0042056 [chemoattractant activity]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045785 [positive regulation of cell adhesion]
GO:0048246 [macrophage chemotaxis]
GO:0048247 [lymphocyte chemotaxis]
GO:0050708 [regulation of protein secretion]
GO:0050715 [positive regulation of cytokine secretion]
GO:0050716 [positive regulation of interleukin-1 secretion]
GO:0050728 [negative regulation of inflammatory response]
GO:0050918 [positive chemotaxis]
GO:0070062 [extracellular exosome]
GO:0071682 [endocytic vesicle lumen]
Show all
 122 aa
13.5 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.