Tissue expression of SAA1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SAA1
Gene description	Serum amyloid A1
Protein class	Disease related genes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (adipose tissue, liver)
GTEx:	Tissue enriched (liver)
FANTOM5:	Tissue enriched (liver)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (adipose tissue, liver)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (liver)

GENE INFORMATION
Gene name	SAA1 (HGNC Symbol)
Synonyms	PIG4, SAA, TP53I4
Description	Serum amyloid A1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Jun 2012]
Chromosome	11
Cytoband	p15.1
Chromosome location (bp)	18266174 - 18269977
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173432 (version 83.38)
Entrez gene	6288
UniProt	P0DJI8 (UniProt - Evidence at protein level)
neXtProt	NX_P0DJI8
Antibodypedia	SAA1 antibodies

PROTEIN BROWSER

SAA1-001	SAA1-002	SAA1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SAA1-001 ENSP00000348918 ENST00000356524	P0DJI8 [Direct mapping] Serum amyloid A-1 protein Amyloid protein A Serum amyloid protein A(2-104) Serum amyloid protein A(3-104) Serum amyloid protein A(2-103) Serum amyloid protein A(2-102) Serum amyloid protein A(4-101) Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000187 [activation of MAPK activity] GO:0001664 [G-protein coupled receptor binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005829 [cytosol] GO:0005881 [cytoplasmic microtubule] GO:0006898 [receptor-mediated endocytosis] GO:0006953 [acute-phase response] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0008201 [heparin binding] GO:0030168 [platelet activation] GO:0030593 [neutrophil chemotaxis] GO:0034364 [high-density lipoprotein particle] GO:0042056 [chemoattractant activity] GO:0044267 [cellular protein metabolic process] GO:0045087 [innate immune response] GO:0045785 [positive regulation of cell adhesion] GO:0048246 [macrophage chemotaxis] GO:0048247 [lymphocyte chemotaxis] GO:0050708 [regulation of protein secretion] GO:0050715 [positive regulation of cytokine secretion] GO:0050716 [positive regulation of interleukin-1 secretion] GO:0050728 [negative regulation of inflammatory response] GO:0050918 [positive chemotaxis] GO:0070062 [extracellular exosome] GO:0071682 [endocytic vesicle lumen] Show all	122 aa 13.5 kDa	Yes	0
SAA1-002 ENSP00000436866 ENST00000532858	E9PQD6 [Direct mapping] Serum amyloid A protein Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006953 [acute-phase response] GO:0034364 [high-density lipoprotein particle] GO:0042056 [chemoattractant activity] GO:0050918 [positive chemotaxis] Show all	122 aa 13.5 kDa	Yes	0
SAA1-003 ENSP00000384906 ENST00000405158	P0DJI8 [Direct mapping] Serum amyloid A-1 protein Amyloid protein A Serum amyloid protein A(2-104) Serum amyloid protein A(3-104) Serum amyloid protein A(2-103) Serum amyloid protein A(2-102) Serum amyloid protein A(4-101) Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000187 [activation of MAPK activity] GO:0001664 [G-protein coupled receptor binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005829 [cytosol] GO:0005881 [cytoplasmic microtubule] GO:0006898 [receptor-mediated endocytosis] GO:0006953 [acute-phase response] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0008201 [heparin binding] GO:0030168 [platelet activation] GO:0030593 [neutrophil chemotaxis] GO:0034364 [high-density lipoprotein particle] GO:0042056 [chemoattractant activity] GO:0044267 [cellular protein metabolic process] GO:0045087 [innate immune response] GO:0045785 [positive regulation of cell adhesion] GO:0048246 [macrophage chemotaxis] GO:0048247 [lymphocyte chemotaxis] GO:0050708 [regulation of protein secretion] GO:0050715 [positive regulation of cytokine secretion] GO:0050716 [positive regulation of interleukin-1 secretion] GO:0050728 [negative regulation of inflammatory response] GO:0050918 [positive chemotaxis] GO:0070062 [extracellular exosome] GO:0071682 [endocytic vesicle lumen] Show all	122 aa 13.5 kDa	Yes	0