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FKBP2

GENERAL INFORMATION

Gene name

 FKBP2

Gene description

 FK506 binding protein 2, 13kDa

Protein class

 Enzymes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues, including immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA049405 , CAB025561
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA049405
CAB025561

GENE INFORMATION

Gene name

 FKBP2 (HGNC Symbol)

Synonyms

 FKBP-13, PPIase

Description

 FK506 binding protein 2, 13kDa (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]

Chromosome

 11

Cytoband

 q13.1

Chromosome location (bp)

 64241003 - 64244132

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000173486 (version 83.38)

Entrez gene

 2286

UniProt

 P26885 (UniProt - Evidence at protein level)

neXtProt

 NX_P26885

Antibodypedia

 FKBP2 antibodies

PROTEIN BROWSER
FKBP2-001
FKBP2-003
FKBP2-004
FKBP2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FKBP2-001
ENSP00000378046
ENST00000394540
P26885 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase FKBP2
Q53XJ5 [Target identity:100%; Query identity:100%]
Peptidyl-prolyl cis-trans isomerase
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Enzymes
   ENZYME proteins
   Isomerase
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005515 [protein binding]
GO:0005528 [FK506 binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006457 [protein folding]
GO:0061077 [chaperone-mediated protein folding]
GO:0070062 [extracellular exosome]
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 142 aa
15.6 kDa 		Yes 0
FKBP2-003
ENSP00000310935
ENST00000309366
P26885 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase FKBP2
Q53XJ5 [Target identity:100%; Query identity:100%]
Peptidyl-prolyl cis-trans isomerase
Show all
Enzymes
   ENZYME proteins
   Isomerase
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005515 [protein binding]
GO:0005528 [FK506 binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006457 [protein folding]
GO:0061077 [chaperone-mediated protein folding]
GO:0070062 [extracellular exosome]
Show all
 142 aa
15.6 kDa 		Yes 0
FKBP2-004
ENSP00000398147
ENST00000449942
P26885 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase FKBP2
Q53XJ5 [Target identity:100%; Query identity:100%]
Peptidyl-prolyl cis-trans isomerase
Show all
Enzymes
   ENZYME proteins
   Isomerase
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005515 [protein binding]
GO:0005528 [FK506 binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006457 [protein folding]
GO:0061077 [chaperone-mediated protein folding]
GO:0070062 [extracellular exosome]
Show all
 142 aa
15.6 kDa 		Yes 0
FKBP2-005
ENSP00000438749
ENST00000535135
F5H0N4 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006457 [protein folding]
GO:0061077 [chaperone-mediated protein folding]
Show all
 102 aa
11.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.