Tissue expression of FKBP2 - Summary - The Human Protein Atlas

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FKBP2

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	FKBP2
Gene description	FK506 binding protein 2, 13kDa
Protein class	Enzymes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues, including immune cells.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA049405 , CAB025561
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	FKBP2 (HGNC Symbol)
Synonyms	FKBP-13, PPIase
Description	FK506 binding protein 2, 13kDa (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]
Chromosome	11
Cytoband	q13.1
Chromosome location (bp)	64241003 - 64244132
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173486 (version 83.38)
Entrez gene	2286
UniProt	P26885 (UniProt - Evidence at protein level)
neXtProt	NX_P26885
Antibodypedia	FKBP2 antibodies

PROTEIN BROWSER

FKBP2-001	FKBP2-003	FKBP2-004	FKBP2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FKBP2-001 ENSP00000378046 ENST00000394540	P26885 [Direct mapping] Peptidyl-prolyl cis-trans isomerase FKBP2 Q53XJ5 [Target identity:100%; Query identity:100%] Peptidyl-prolyl cis-trans isomerase Show all	Enzymes ENZYME proteins Isomerase MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005515 [protein binding] GO:0005528 [FK506 binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0061077 [chaperone-mediated protein folding] GO:0070062 [extracellular exosome] Show all	142 aa 15.6 kDa	Yes	0
FKBP2-003 ENSP00000310935 ENST00000309366	P26885 [Direct mapping] Peptidyl-prolyl cis-trans isomerase FKBP2 Q53XJ5 [Target identity:100%; Query identity:100%] Peptidyl-prolyl cis-trans isomerase Show all	Enzymes ENZYME proteins Isomerase MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005515 [protein binding] GO:0005528 [FK506 binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0061077 [chaperone-mediated protein folding] GO:0070062 [extracellular exosome] Show all	142 aa 15.6 kDa	Yes	0
FKBP2-004 ENSP00000398147 ENST00000449942	P26885 [Direct mapping] Peptidyl-prolyl cis-trans isomerase FKBP2 Q53XJ5 [Target identity:100%; Query identity:100%] Peptidyl-prolyl cis-trans isomerase Show all	Enzymes ENZYME proteins Isomerase MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005515 [protein binding] GO:0005528 [FK506 binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0061077 [chaperone-mediated protein folding] GO:0070062 [extracellular exosome] Show all	142 aa 15.6 kDa	Yes	0
FKBP2-005 ENSP00000438749 ENST00000535135	F5H0N4 [Direct mapping] Peptidyl-prolyl cis-trans isomerase Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0061077 [chaperone-mediated protein folding] Show all	102 aa 11.3 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.