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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CCR9
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

CCR9

Gene description

Chemokine (C-C motif) receptor 9

Protein class

CD markers
G-protein coupled receptors
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Not detected
HPA (cell line):Cell line enriched (MOLT-4)
HPA (normal tissue):Group enriched (appendix, duodenum, small intestine, spleen)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in subsets of immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

Presumed off target binding observed and disregarded. Pending retesting.

Reliability score

Uncertain based on 1 antibody.
CAB006839
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

CAB006839

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues displayed moderate to strong cytoplasmic immunoreactivity. Most colorectal cancers were weakly stained.

GENE INFORMATION

Gene name

CCR9 (HGNC Symbol)

Synonyms

CDw199, GPR-9-6, GPR28

Description

Chemokine (C-C motif) receptor 9 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Chromosome

3

Cytoband

p21.31

Chromosome location (bp)

45886504 - 45903177

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000173585 (version 83.38)

Entrez gene

10803

UniProt

P51686 (UniProt - Evidence at protein level)

neXtProt

NX_P51686

Antibodypedia

CCR9 antibodies

PROTEIN BROWSER

CCR9-001
CCR9-002
CCR9-003
CCR9-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CCR9-001
ENSP00000350256
ENST00000357632
P51686 [Direct mapping]
C-C chemokine receptor type 9
Show all
CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004950 [chemokine receptor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006935 [chemotaxis]
GO:0006955 [immune response]
GO:0006968 [cellular defense response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0016493 [C-C chemokine receptor activity]
GO:0070098 [chemokine-mediated signaling pathway]
Show all
369 aa
42 kDa
No 7
CCR9-002
ENSP00000379292
ENST00000395963
P51686 [Direct mapping]
C-C chemokine receptor type 9
Show all
CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004950 [chemokine receptor activity]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0006968 [cellular defense response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0070098 [chemokine-mediated signaling pathway]
Show all
357 aa
40.7 kDa
No 7
CCR9-003
ENSP00000393267
ENST00000422395
C9JWC0 [Direct mapping]
C-C chemokine receptor type 9
Show all
Predicted intracellular proteins
Show all
107 aa
11.4 kDa
No 0
CCR9-201
ENSP00000348260
ENST00000355983
P51686 [Direct mapping]
C-C chemokine receptor type 9
Show all
CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004950 [chemokine receptor activity]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0006968 [cellular defense response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0070098 [chemokine-mediated signaling pathway]
Show all
357 aa
40.7 kDa
No 7

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