Expression of CCR9 in cancer - Summary - The Human Protein Atlas

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CCR9

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CCR9
Gene description	Chemokine (C-C motif) receptor 9
Protein class	CD markers G-protein coupled receptors Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enriched (MOLT-4)
HPA (normal tissue):	Group enriched (appendix, duodenum, small intestine, spleen)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in subsets of immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded. Pending retesting.
Reliability score	Uncertain based on 1 antibody. CAB006839
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB006839

GENE INFORMATION
Gene name	CCR9 (HGNC Symbol)
Synonyms	CDw199, GPR-9-6, GPR28
Description	Chemokine (C-C motif) receptor 9 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	45886504 - 45903177
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173585 (version 83.38)
Entrez gene	10803
UniProt	P51686 (UniProt - Evidence at protein level)
neXtProt	NX_P51686
Antibodypedia	CCR9 antibodies

PROTEIN BROWSER

CCR9-001	CCR9-002	CCR9-003	CCR9-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCR9-001 ENSP00000350256 ENST00000357632	P51686 [Direct mapping] C-C chemokine receptor type 9 Show all	CD markers G-protein coupled receptors GPCRs excl olfactory receptors Chemokines and chemotactic factors receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004950 [chemokine receptor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006935 [chemotaxis] GO:0006955 [immune response] GO:0006968 [cellular defense response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0016493 [C-C chemokine receptor activity] GO:0070098 [chemokine-mediated signaling pathway] Show all	369 aa 42 kDa	No	7
CCR9-002 ENSP00000379292 ENST00000395963	P51686 [Direct mapping] C-C chemokine receptor type 9 Show all	CD markers G-protein coupled receptors GPCRs excl olfactory receptors Chemokines and chemotactic factors receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004950 [chemokine receptor activity] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0006968 [cellular defense response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0070098 [chemokine-mediated signaling pathway] Show all	357 aa 40.7 kDa	No	7
CCR9-003 ENSP00000393267 ENST00000422395	C9JWC0 [Direct mapping] C-C chemokine receptor type 9 Show all	Predicted intracellular proteins Show all		107 aa 11.4 kDa	No	0
CCR9-201 ENSP00000348260 ENST00000355983	P51686 [Direct mapping] C-C chemokine receptor type 9 Show all	CD markers G-protein coupled receptors GPCRs excl olfactory receptors Chemokines and chemotactic factors receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004950 [chemokine receptor activity] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0006968 [cellular defense response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0070098 [chemokine-mediated signaling pathway] Show all	357 aa 40.7 kDa	No	7

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.