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PC

GENERAL INFORMATION

Gene name

 PC

Gene description

 Pyruvate carboxylase

Protein class

 Citric acid cycle related proteins
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Granular cytoplasmic expression at variable levels in most tissues. High expression in the liver.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA043922 , CAB033742
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PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (unfavourable) and renal cancer (favourable).
Ovarian cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA043922
CAB033742

GENE INFORMATION

Gene name

 PC (HGNC Symbol)

Synonyms

 PCB

Description

 Pyruvate carboxylase (HGNC Symbol)

Entrez gene summary

 This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q13.2

Chromosome location (bp)

 66848233 - 66958376

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000173599 (version 83.38)

Entrez gene

 5091

UniProt

 P11498 (UniProt - Evidence at protein level)

neXtProt

 NX_P11498

Antibodypedia

 PC antibodies

PROTEIN BROWSER
PC-001
PC-003
PC-005
PC-011
PC-201
PC-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PC-001
ENSP00000377530
ENST00000393958
P11498 [Direct mapping]
Pyruvate carboxylase, mitochondrial
A0A024R5C5 [Target identity:100%; Query identity:100%]
Pyruvate carboxylase
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Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Plasma proteins
Citric acid cycle related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003824 [catalytic activity]
GO:0004075 [biotin carboxylase activity]
GO:0004736 [pyruvate carboxylase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006090 [pyruvate metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006629 [lipid metabolic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006768 [biotin metabolic process]
GO:0009374 [biotin binding]
GO:0010629 [negative regulation of gene expression]
GO:0019074 [viral RNA genome packaging]
GO:0044281 [small molecule metabolic process]
GO:0044791 [positive regulation by host of viral release from host cell]
GO:0044794 [positive regulation by host of viral process]
GO:0046872 [metal ion binding]
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 1178 aa
129.6 kDa 		No 0
PC-003
ENSP00000434192
ENST00000524491
E9PRE7 [Direct mapping]
Pyruvate carboxylase, mitochondrial
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Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004075 [biotin carboxylase activity]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0046872 [metal ion binding]
Show all
 489 aa
53.4 kDa 		No 0
PC-005
ENSP00000377527
ENST00000393955
P11498 [Direct mapping]
Pyruvate carboxylase, mitochondrial
A0A024R5C5 [Target identity:100%; Query identity:100%]
Pyruvate carboxylase
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Plasma proteins
Citric acid cycle related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003824 [catalytic activity]
GO:0004075 [biotin carboxylase activity]
GO:0004736 [pyruvate carboxylase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006090 [pyruvate metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006629 [lipid metabolic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006768 [biotin metabolic process]
GO:0009374 [biotin binding]
GO:0010629 [negative regulation of gene expression]
GO:0019074 [viral RNA genome packaging]
GO:0044281 [small molecule metabolic process]
GO:0044791 [positive regulation by host of viral release from host cell]
GO:0044794 [positive regulation by host of viral process]
GO:0046872 [metal ion binding]
Show all
 1178 aa
129.6 kDa 		No 0
PC-011
ENSP00000435905
ENST00000529047
E9PS68 [Direct mapping]
Pyruvate carboxylase, mitochondrial
Show all
Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005739 [mitochondrion]
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 298 aa
32.7 kDa 		No 0
PC-201
ENSP00000377532
ENST00000393960
P11498 [Direct mapping]
Pyruvate carboxylase, mitochondrial
A0A024R5C5 [Target identity:100%; Query identity:100%]
Pyruvate carboxylase
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Plasma proteins
Citric acid cycle related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003824 [catalytic activity]
GO:0004075 [biotin carboxylase activity]
GO:0004736 [pyruvate carboxylase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006090 [pyruvate metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006107 [oxaloacetate metabolic process]
GO:0006629 [lipid metabolic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006768 [biotin metabolic process]
GO:0009374 [biotin binding]
GO:0010629 [negative regulation of gene expression]
GO:0019074 [viral RNA genome packaging]
GO:0031406 [carboxylic acid binding]
GO:0044281 [small molecule metabolic process]
GO:0044791 [positive regulation by host of viral release from host cell]
GO:0044794 [positive regulation by host of viral process]
GO:0046872 [metal ion binding]
Show all
 1178 aa
129.6 kDa 		No 0
PC-202
ENSP00000486373
ENST00000628663
E9PRE7 [Direct mapping]
Pyruvate carboxylase, mitochondrial
Show all
Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004075 [biotin carboxylase activity]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0046872 [metal ion binding]
Show all
 489 aa
53.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.