Cancer cells showed moderate cytoplasmic immunoreactivity which was combined with membranous staining in a few cases. Fractions of cholangiocarcinomas, ovarian, urothelial and pancreatic cancers displayed strong positivity.
TAS1R1 (HGNC Symbol)
GPR70, T1R1, TR1
Taste receptor, type 1, member 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]