Expression of TAS1R1 in cancer - Summary - The Human Protein Atlas

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TAS1R1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TAS1R1
Gene description	Taste receptor, type 1, member 1
Protein class	G-protein coupled receptors Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HDLM-2, Hep G2, LHCN-M2)
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA034579 , HPA034580
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA034579	HPA034580

GENE INFORMATION
Gene name	TAS1R1 (HGNC Symbol)
Synonyms	GPR70, T1R1, TR1
Description	Taste receptor, type 1, member 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Chromosome	1
Cytoband	p36.31
Chromosome location (bp)	6555181 - 6579757
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000173662 (version 83.38)
Entrez gene	80835
UniProt	Q7RTX1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q7RTX1
Antibodypedia	TAS1R1 antibodies

PROTEIN BROWSER

TAS1R1-001	TAS1R1-002	TAS1R1-003	TAS1R1-004	TAS1R1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TAS1R1-001 ENSP00000331867 ENST00000333172	Q7RTX1 [Direct mapping] Taste receptor type 1 member 1 Show all	Family 3 (C) receptors Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0008527 [taste receptor activity] GO:0016021 [integral component of membrane] GO:0046982 [protein heterodimerization activity] GO:0050912 [detection of chemical stimulus involved in sensory perception of taste] GO:0050917 [sensory perception of umami taste] Show all	841 aa 93.1 kDa	Yes	7
TAS1R1-002 ENSP00000414166 ENST00000411823	H7C3W7 [Direct mapping] Taste receptor type 1 member 1 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	406 aa 44.2 kDa	No	0
TAS1R1-003 ENSP00000408448 ENST00000415267	H0Y6X0 [Direct mapping] Taste receptor type 1 member 1 Show all	Predicted intracellular proteins Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	247 aa 26.9 kDa	No	0
TAS1R1-004 ENSP00000312558 ENST00000351136	Q7RTX1 [Direct mapping] Taste receptor type 1 member 1 Show all	Family 3 (C) receptors Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0008527 [taste receptor activity] GO:0016021 [integral component of membrane] GO:0046982 [protein heterodimerization activity] GO:0050912 [detection of chemical stimulus involved in sensory perception of taste] GO:0050917 [sensory perception of umami taste] Show all	587 aa 65.1 kDa	Yes	7
TAS1R1-201 ENSP00000327705 ENST00000328191	A0A0A0MR63 [Direct mapping] Taste receptor type 1 member 1 Show all	Predicted intracellular proteins Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	304 aa 32.9 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.