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TAS1R1

GENERAL INFORMATION

Gene name

 TAS1R1

Gene description

 Taste receptor, type 1, member 1

Protein class

 G-protein coupled receptors
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (testis)
GTEx:Tissue enriched (testis)
FANTOM5:Tissue enriched (salivary gland)

Protein evidence

 Evidence at transcript level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA034579 , HPA034580
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (salivary gland)

GENE INFORMATION

Gene name

 TAS1R1 (HGNC Symbol)

Synonyms

 GPR70, T1R1, TR1

Description

 Taste receptor, type 1, member 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Chromosome

 1

Cytoband

 p36.31

Chromosome location (bp)

 6555181 - 6579757

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000173662 (version 83.38)

Entrez gene

 80835

UniProt

 Q7RTX1 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q7RTX1

Antibodypedia

 TAS1R1 antibodies

PROTEIN BROWSER
TAS1R1-001
TAS1R1-002
TAS1R1-003
TAS1R1-004
TAS1R1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TAS1R1-001
ENSP00000331867
ENST00000333172
Q7RTX1 [Direct mapping]
Taste receptor type 1 member 1
Show all
   Family 3 (C) receptors
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0005886 [plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008527 [taste receptor activity]
GO:0016021 [integral component of membrane]
GO:0046982 [protein heterodimerization activity]
GO:0050912 [detection of chemical stimulus involved in sensory perception of taste]
GO:0050917 [sensory perception of umami taste]
Show all
 841 aa
93.1 kDa 		Yes 7
TAS1R1-002
ENSP00000414166
ENST00000411823
H7C3W7 [Direct mapping]
Taste receptor type 1 member 1
Show all
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
Show all
 406 aa
44.2 kDa 		No 0
TAS1R1-003
ENSP00000408448
ENST00000415267
H0Y6X0 [Direct mapping]
Taste receptor type 1 member 1
Show all
Predicted intracellular proteins
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
Show all
 247 aa
26.9 kDa 		No 0
TAS1R1-004
ENSP00000312558
ENST00000351136
Q7RTX1 [Direct mapping]
Taste receptor type 1 member 1
Show all
   Family 3 (C) receptors
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0005886 [plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008527 [taste receptor activity]
GO:0016021 [integral component of membrane]
GO:0046982 [protein heterodimerization activity]
GO:0050912 [detection of chemical stimulus involved in sensory perception of taste]
GO:0050917 [sensory perception of umami taste]
Show all
 587 aa
65.1 kDa 		Yes 7
TAS1R1-201
ENSP00000327705
ENST00000328191
A0A0A0MR63 [Direct mapping]
Taste receptor type 1 member 1
Show all
Predicted intracellular proteins
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
Show all
 304 aa
32.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.