We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
ADGRG2
  • premium

    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ADGRG2

Gene description

Adhesion G protein-coupled receptor G2

Protein class

G-protein coupled receptors
Plasma proteins
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

10
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enhanced (ovarian cancer)
HPA (cell line):Cell line enhanced (BEWO, NTERA-2, SH-SY5Y, U-2197)
HPA (normal tissue):Tissue enriched (epididymis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression in epididymis glandular cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

Supported based on 2 antibodies.
HPA001478 , HPA050029
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enhanced (ovarian cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA001478
HPA050029

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Weak to moderate cytoplasmic positivity was observed in a subset of tumor cells in few cases of several cancers.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Weak nucleolar staining was observed in a few cases of a majority of all cancer types. Remaining cancer tissues were negative.

GENE INFORMATION

Gene name

ADGRG2 (HGNC Symbol)

Synonyms

EDDM6, GPR64, HE6, TM7LN2

Description

Adhesion G protein-coupled receptor G2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the G protein-coupled receptor family described as an epididymis-specific transmembrane protein. The encoded protein may be proteolytically processed as it contains a motif shown to be a protein scission motif in some members of this family (PMID: 11973329). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Chromosome

X

Cytoband

p22.13

Chromosome location (bp)

18989309 - 19122637

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000173698 (version 83.38)

Entrez gene

10149

UniProt

Q8IZP9 (UniProt - Evidence at protein level)

neXtProt

NX_Q8IZP9

Antibodypedia

ADGRG2 antibodies

PROTEIN BROWSER

ADGRG2-001
ADGRG2-002
ADGRG2-003
ADGRG2-005
ADGRG2-006
ADGRG2-007
ADGRG2-008
ADGRG2-201
ADGRG2-202
ADGRG2-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADGRG2-001
ENSP00000369202
ENST00000379873
Q8IZP9 [Direct mapping]
Adhesion G-protein coupled receptor G2
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007283 [spermatogenesis]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0070062 [extracellular exosome]
Show all
966 aa
106.4 kDa
No 8
ADGRG2-002
ENSP00000350152
ENST00000357544
Q8IZP9 [Direct mapping]
Adhesion G-protein coupled receptor G2
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007283 [spermatogenesis]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0070062 [extracellular exosome]
Show all
987 aa
108.5 kDa
No 8
ADGRG2-003
ENSP00000369198
ENST00000379869
Q8IZP9 [Direct mapping]
Adhesion G-protein coupled receptor G2
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007283 [spermatogenesis]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0070062 [extracellular exosome]
Show all
1017 aa
111.6 kDa
No 8
ADGRG2-005
ENSP00000353421
ENST00000360279
Q8IZP9 [Direct mapping]
Adhesion G-protein coupled receptor G2
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007283 [spermatogenesis]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0070062 [extracellular exosome]
Show all
995 aa
109.2 kDa
No 8
ADGRG2-006
ENSP00000350680
ENST00000357991
Q8IZP9 [Direct mapping]
Adhesion G-protein coupled receptor G2
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007283 [spermatogenesis]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0070062 [extracellular exosome]
Show all
1014 aa
111.3 kDa
No 8
ADGRG2-007
ENSP00000349015
ENST00000356606
Q8IZP9 [Direct mapping]
Adhesion G-protein coupled receptor G2
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007283 [spermatogenesis]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0070062 [extracellular exosome]
Show all
1003 aa
110 kDa
No 8
ADGRG2-008
ENSP00000344972
ENST00000340581
Q8IZP9 [Direct mapping]
Adhesion G-protein coupled receptor G2
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007283 [spermatogenesis]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0070062 [extracellular exosome]
Show all
898 aa
98.7 kDa
No 8
ADGRG2-201
ENSP00000346845
ENST00000354791
Q8IZP9 [Direct mapping]
Adhesion G-protein coupled receptor G2
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007283 [spermatogenesis]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0070062 [extracellular exosome]
Show all
898 aa
98.7 kDa
No 8
ADGRG2-202
ENSP00000369205
ENST00000379876
Q8IZP9 [Direct mapping]
Adhesion G-protein coupled receptor G2
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007283 [spermatogenesis]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0070062 [extracellular exosome]
Show all
993 aa
109.2 kDa
No 8
ADGRG2-203
ENSP00000369207
ENST00000379878
Q8IZP9 [Direct mapping]
Adhesion G-protein coupled receptor G2
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007283 [spermatogenesis]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0070062 [extracellular exosome]
Show all
1001 aa
110 kDa
No 8

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.