Expression of MUC13 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

MUC13

premium

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MUC13
Gene description	Mucin 13, cell surface associated
Protein class	Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (colorectal cancer, stomach cancer)
HPA (cell line):	Cell line enhanced (A549, CACO-2, CAPAN-2, Karpas-707)
HPA (normal tissue):	Group enriched (colon, duodenum, rectum, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in gastrointestinal goblet cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA045163
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (colorectal cancer, stomach cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045163

GENE INFORMATION
Gene name	MUC13 (HGNC Symbol)
Synonyms	DRCC1
Description	Mucin 13, cell surface associated (HGNC Symbol)
Entrez gene summary	Epithelial mucins, such as MUC13, are a family of secreted and cell surface glycoproteins expressed by ductal and glandular epithelial tissues (Williams et al., 2001 [PubMed 11278439]).[supplied by OMIM, Jul 2008]
Chromosome	3
Cytoband	q21.2
Chromosome location (bp)	124905442 - 124953819
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173702 (version 83.38)
Entrez gene	56667
UniProt	Q9H3R2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H3R2
Antibodypedia	MUC13 antibodies

PROTEIN BROWSER

MUC13-001	MUC13-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MUC13-001 ENSP00000485028 ENST00000616727	Q9H3R2 [Direct mapping] Mucin-13 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005796 [Golgi lumen] GO:0005829 [cytosol] GO:0006493 [protein O-linked glycosylation] GO:0016021 [integral component of membrane] GO:0016266 [O-glycan processing] GO:0016324 [apical plasma membrane] GO:0030277 [maintenance of gastrointestinal epithelium] GO:0042803 [protein homodimerization activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] Show all	512 aa 54.6 kDa	Yes	1
MUC13-003 ENSP00000418660 ENST00000478191	C9IZG1 [Direct mapping] Mucin-13 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	184 aa 19.9 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.