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WFIKKN2

GENERAL INFORMATION

Gene name

 WFIKKN2

Gene description

 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (glioma, testis cancer)
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (ovary)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (glioma, testis cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 WFIKKN2 (HGNC Symbol)

Synonyms

 WFDC20B, WFIKKNRP

Description

 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 (HGNC Symbol)

Entrez gene summary

 The WFIKKN1 protein contains a WAP domain, follistatin domain, immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. This gene encodes a WFIKKN1-related protein which has the same domain organization as the WFIKKN1 protein. The WAP-type, follistatin type, Kunitz-type, and NTR-type protease inhibitory domains may control the action of multiple types of proteases. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q21.33

Chromosome location (bp)

 50834650 - 50842348

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000173714 (version 83.38)

Entrez gene

 124857

UniProt

 Q8TEU8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TEU8

Antibodypedia

 WFIKKN2 antibodies

PROTEIN BROWSER
WFIKKN2-001
WFIKKN2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
WFIKKN2-001
ENSP00000311184
ENST00000311378
Q8TEU8 [Direct mapping]
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2
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   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001501 [skeletal system development]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008191 [metalloendopeptidase inhibitor activity]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0030414 [peptidase inhibitor activity]
GO:0032091 [negative regulation of protein binding]
GO:0043392 [negative regulation of DNA binding]
GO:0048747 [muscle fiber development]
GO:0060021 [palate development]
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 576 aa
63.9 kDa 		Yes 0
WFIKKN2-002
ENSP00000405889
ENST00000426127
C9J6G4 [Direct mapping]
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0010951 [negative regulation of endopeptidase activity]
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 483 aa
53.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.