Tissue expression of WFIKKN2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	WFIKKN2
Gene description	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (ovary)
GTEx:	Tissue enriched (ovary)
FANTOM5:	Tissue enriched (ovary)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (ovary)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (ovary)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (ovary)

GENE INFORMATION
Gene name	WFIKKN2 (HGNC Symbol)
Synonyms	WFDC20B, WFIKKNRP
Description	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 (HGNC Symbol)
Entrez gene summary	The WFIKKN1 protein contains a WAP domain, follistatin domain, immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. This gene encodes a WFIKKN1-related protein which has the same domain organization as the WFIKKN1 protein. The WAP-type, follistatin type, Kunitz-type, and NTR-type protease inhibitory domains may control the action of multiple types of proteases. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.33
Chromosome location (bp)	50834650 - 50842348
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173714 (version 83.38)
Entrez gene	124857
UniProt	Q8TEU8 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TEU8
Antibodypedia	WFIKKN2 antibodies

PROTEIN BROWSER

WFIKKN2-001	WFIKKN2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
WFIKKN2-001 ENSP00000311184 ENST00000311378	Q8TEU8 [Direct mapping] WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008191 [metalloendopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] GO:0030414 [peptidase inhibitor activity] GO:0032091 [negative regulation of protein binding] GO:0043392 [negative regulation of DNA binding] GO:0048747 [muscle fiber development] GO:0060021 [palate development] Show all	576 aa 63.9 kDa	Yes	0
WFIKKN2-002 ENSP00000405889 ENST00000426127	C9J6G4 [Direct mapping] WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0010951 [negative regulation of endopeptidase activity] Show all	483 aa 53.3 kDa	No	0